Hyperosmolar hyperglycemic coma in an infant with neonatal diabetes mellitus

Zachary C. Foughty, Kristen Moryan-Blanchard, Erin B. Henkel, Claire Gahm

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Neonatal diabetes mellitus (NDM) is a rare disease distinct from type 1 diabetes mellitus (T1DM). While T1DM results from autoimmune destruction of pancreatic beta cells, NDM arises from genetic mutations to insulin production and secretion pathways. We present a case of an infant presenting to the emergency department with shock and poor responsiveness, found to have neonatal DM with hyperosmotic hyperglycemic syndrome (HHS). This report distinguishes NDM from T1DM, illustrating the subtle but clinically significant differences in pathophysiology and implications for initial management of NDM in the emergency department setting.

Original languageEnglish (US)
JournalAmerican Journal of Emergency Medicine
StateAccepted/In press - 2021
Externally publishedYes


  • Diabetes mellitus
  • Diabetic ketoacidosis
  • Hyperglycemic hyperosmolar nonketotic coma
  • Pediatric emergency medicine
  • Permanent neonatal

ASJC Scopus subject areas

  • Emergency Medicine


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