TY - JOUR
T1 - Hyperkalemia and Renin Deficiency
AU - Kaplan, Norman M
PY - 1972/9/21
Y1 - 1972/9/21
N2 - Hyperkalemia can be caused by a deficiency of the salt-retaining hormone, aldosterone. As most readily seen in patients with adrenal insufficiency, the lack of salt-retaining hormone leads to decreased renal tubular reabsorption of sodium. Since potassium is excreted in exchange for sodium reabsorbed, potassium excretion is decreased, resulting in hyperkalemia. The deficiency of aldosterone may be selective. The first report of a patient with isolated aldosterone deficiency clearly defined the typical features of the syndrome: elderly patients with mild to moderate renal insufficiency in whom severe hyperkalemia develops, particularly when they are deprived or depleted of sodium, the hyperkalemia manifested.
AB - Hyperkalemia can be caused by a deficiency of the salt-retaining hormone, aldosterone. As most readily seen in patients with adrenal insufficiency, the lack of salt-retaining hormone leads to decreased renal tubular reabsorption of sodium. Since potassium is excreted in exchange for sodium reabsorbed, potassium excretion is decreased, resulting in hyperkalemia. The deficiency of aldosterone may be selective. The first report of a patient with isolated aldosterone deficiency clearly defined the typical features of the syndrome: elderly patients with mild to moderate renal insufficiency in whom severe hyperkalemia develops, particularly when they are deprived or depleted of sodium, the hyperkalemia manifested.
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U2 - 10.1056/NEJM197209212871210
DO - 10.1056/NEJM197209212871210
M3 - Editorial
C2 - 5055213
AN - SCOPUS:0015518778
SN - 0028-4793
VL - 287
SP - 611
EP - 612
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 12
ER -