TY - JOUR
T1 - Hyperglycemia as a risk factor for cancer progression
AU - Ryu, Tae Young
AU - Park, Jiyoung
AU - Scherer, Philipp E.
N1 - Publisher Copyright:
© 2014 Korean Diabetes Association.
PY - 2014
Y1 - 2014
N2 - As the prevalence of diabetes mellitus is substantially increasing worldwide, associated diseases such as renal failure, cardiovascular diseases, fatty liver, and cancers have also increased. A number of cancers such as pancreatic, liver, breast, and female reproductive cancers have shown an increased prevalence and a higher mortality rate in diabetic patients compared to healthy subjects. Thus, this suggests an association between diabetes, especially type 2 diabetes and cancer incidence and progression. Recent studies have suggested that hyperinsulinemia, chronic inflammation and hyperglycemia, all frequently seen in diabetics, may lead to increased tumor growth; the underlying molecular mechanisms of this association are not fully understood. In particular, chronic hyperglycemic episodes could serve as a direct or indirect mediator of the increase in tumor cell growth. Here, we will discuss our current understanding how hyperglycemia and cancer risk may be linked, and what the implications are for the treatment of diabetic cancer patients.
AB - As the prevalence of diabetes mellitus is substantially increasing worldwide, associated diseases such as renal failure, cardiovascular diseases, fatty liver, and cancers have also increased. A number of cancers such as pancreatic, liver, breast, and female reproductive cancers have shown an increased prevalence and a higher mortality rate in diabetic patients compared to healthy subjects. Thus, this suggests an association between diabetes, especially type 2 diabetes and cancer incidence and progression. Recent studies have suggested that hyperinsulinemia, chronic inflammation and hyperglycemia, all frequently seen in diabetics, may lead to increased tumor growth; the underlying molecular mechanisms of this association are not fully understood. In particular, chronic hyperglycemic episodes could serve as a direct or indirect mediator of the increase in tumor cell growth. Here, we will discuss our current understanding how hyperglycemia and cancer risk may be linked, and what the implications are for the treatment of diabetic cancer patients.
KW - Cancer risk
KW - Diabetes
KW - Hyperglycemia
KW - Therapeutics
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U2 - 10.4093/dmj.2014.38.5.330
DO - 10.4093/dmj.2014.38.5.330
M3 - Review article
C2 - 25349819
AN - SCOPUS:84908891835
SN - 2233-6079
VL - 38
SP - 330
EP - 336
JO - Diabetes and Metabolism Journal
JF - Diabetes and Metabolism Journal
IS - 5
ER -