Hyperglucagonemia in Diabetes

Robert S. Sherwin, Philip Felig, A. J. Barnes, S. R. Bloom, K. G.M.M. Alberti, D. G. Johnston, Roger H Unger

Research output: Contribution to journalLetterpeer-review

3 Scopus citations


To the Editor: We wish to challenge the conclusions as well as the assertions raised by Raskin and Unger in their article in the August 31 issue of the Journal. First of all, regarding the effect of hyperglucagonemia on glucose regulation in insulin-treated diabetes, the authors cite the studies of Sherwin et al.1 and Raskin and Unger,2 which are in conflict. However, they fail to mention the data of Clarke et al.3 In the latter study, in which physiologic amounts of glucagon were infused in diabetic patients, the authors conclude that “elevated plasma glucagon concentrations seen in most diabetic.

Original languageEnglish (US)
Pages (from-to)1366-1368
Number of pages3
JournalNew England Journal of Medicine
Issue number24
StatePublished - Dec 14 1978

ASJC Scopus subject areas

  • Medicine(all)


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