Hyperglucagonemia in Diabetes

To the Editor: We wish to challenge the conclusions as well as the assertions raised by Raskin and Unger in their article in the August 31 issue of the Journal. First of all, regarding the effect of hyperglucagonemia on glucose regulation in insulin-treated diabetes, the authors cite the studies of Sherwin et al.¹ and Raskin and Unger,² which are in conflict. However, they fail to mention the data of Clarke et al.³ In the latter study, in which physiologic amounts of glucagon were infused in diabetic patients, the authors conclude that “elevated plasma glucagon concentrations seen in most diabetic.