Hypergastrinemia in Obese Noninsulin-Dependent Diabetes: A Possible Reflection of High Prevalence of Vagal Dysfunction

H. Sasaki, M. Nagulesparan, A. Dubois, E. Straus, I. M. Samloff, W. H. Lawrence, G. C. Johnson, M. L. Sievers, Roger H Unger

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


To elucidate the relation of noninsulin-dependent (type II) diabetes mellitus to plasma levels of gastrin, pepsinogen I, and pepsinogen II, gastric acid secretion, and gastric emptying, we studied diabetic and nondiabetic obese Pima Indian subjects. Fasting and postprandial plasma gastrin concentrations were significantly higher (P < 0.02) in diabetic than in nondiabetic subjects, but gastric acid outputs basally, after an acaloric liquid meal, and in response to betazole were similar in the two groups. Plasma pepsinogen I and pepsinogen II levels were also similar in both groups. A significant negative relation (r = -0.84; P < 0.01) was found between basal gastrin levels and gastric acid production in nondiabetic Indians, but not in diabetic Pimas. The fractional gastric emptying rate of an acaloric liquid meal was significantly decreased in diabetic Pimas (P < 0.01); and at least one test showing abnormal vagal function, as estimated by the Valsalva maneuver, heart rate changes between deep expiration and inspiration, and postural hypotension, was found in every diabetic subject. These findings suggest that hypergastrinemia in type II diabetes is not related to hypochlorhydria, but, instead, results from autonomic dysfunction with slow gastric emptying.

Original languageEnglish (US)
Pages (from-to)744-750
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Issue number4
StatePublished - Apr 1983

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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