Abstract
Humoral hypercalcemia of malignancy is widely associated with tumor production of parathyroid hormone related protein (PTH-rP). This peptide functions in endocrine, autocrine and paracrine mechanisms in a manner similar to PTH; increasing renal uptake of calcium, decreasing retention of phosphorous, and stimulating adenylate cyclase and phospholipase C. Although PTH-rP production has been well documented in neoplasms of the exocrine pancreas, we present here two cases of endocrine pancreatic neoplasms elaborating PTH-rP. We then review the literature of previous cases and delve into the pathophysiology of this peptide.
Original language | English (US) |
---|---|
Pages (from-to) | 270-279 |
Number of pages | 10 |
Journal | Journal of Gastrointestinal Surgery |
Volume | 9 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2005 |
Keywords
- Hypercalcemia
- PTH-rP
- Pancreatic endocrine neoplasm
ASJC Scopus subject areas
- Surgery
- Gastroenterology