Hydroxychloroquine causes severe vacuolar myopathy in a patient with chronic graft-versus-host disease

Javier Bolaños-Meade; Lan Zhou; Ahmet Hoke; Andrea Corse; Georgia Vogelsang; Kathryn R. Wagner

doi:10.1002/ajh.20294

Hydroxychloroquine causes severe vacuolar myopathy in a patient with chronic graft-versus-host disease

Javier Bolaños-Meade, Lan Zhou, Ahmet Hoke, Andrea Corse, Georgia Vogelsang, Kathryn R. Wagner

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A 51-year-old man developed progressive debilitating limb and respiratory muscle weakness while undergoing treatment for chronic graft-versus-host disease secondary to allogeneic bone marrow transplant for mantle cell lymphoma. He had a normal serum creatine kinase level and acetylcholine receptor antibodies were negative. Electromyography showed a severe, nonirritable myopathy and a sensory motor axonal polyneuropathy. A muscle biopsy showed a necrotizing, vacuolar myopathy with many fibers containing autophagic and red-rimmed vacuoles, suggestive of an amphiphilic drug myopathy. The patient's strength and function improved significantly after discontinuation of hydroxychloroquine.

Original language	English (US)
Pages (from-to)	306-309
Number of pages	4
Journal	American Journal of Hematology
Volume	78
Issue number	4
DOIs	https://doi.org/10.1002/ajh.20294
State	Published - Apr 1 2005

Keywords

Graft-versus-host disease
Hydroxychloroquine
Myopathy
Vacuolar myopathy

ASJC Scopus subject areas

Hematology

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10.1002/ajh.20294

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abstract = "A 51-year-old man developed progressive debilitating limb and respiratory muscle weakness while undergoing treatment for chronic graft-versus-host disease secondary to allogeneic bone marrow transplant for mantle cell lymphoma. He had a normal serum creatine kinase level and acetylcholine receptor antibodies were negative. Electromyography showed a severe, nonirritable myopathy and a sensory motor axonal polyneuropathy. A muscle biopsy showed a necrotizing, vacuolar myopathy with many fibers containing autophagic and red-rimmed vacuoles, suggestive of an amphiphilic drug myopathy. The patient's strength and function improved significantly after discontinuation of hydroxychloroquine.",

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AU - Bolaños-Meade, Javier

AU - Zhou, Lan

AU - Hoke, Ahmet

AU - Corse, Andrea

AU - Vogelsang, Georgia

AU - Wagner, Kathryn R.

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AB - A 51-year-old man developed progressive debilitating limb and respiratory muscle weakness while undergoing treatment for chronic graft-versus-host disease secondary to allogeneic bone marrow transplant for mantle cell lymphoma. He had a normal serum creatine kinase level and acetylcholine receptor antibodies were negative. Electromyography showed a severe, nonirritable myopathy and a sensory motor axonal polyneuropathy. A muscle biopsy showed a necrotizing, vacuolar myopathy with many fibers containing autophagic and red-rimmed vacuoles, suggestive of an amphiphilic drug myopathy. The patient's strength and function improved significantly after discontinuation of hydroxychloroquine.

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Hydroxychloroquine causes severe vacuolar myopathy in a patient with chronic graft-versus-host disease

Abstract

Keywords

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