Hydroxamic derivatives of saturated fatty acids as inhibitors of 5-lipoxygenase

L. V. Bondarenko; S. A. Ohiy; V. N. Tsernjuk; I. A. Butovich

doi:10.7124/bc.00041D

Hydroxamic derivatives of saturated fatty acids as inhibitors of 5-lipoxygenase

L. V. Bondarenko, S. A. Ohiy, V. N. Tsernjuk, I. A. Butovich

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Abstract

In experiments in vitro were established inhibitory effects ofhydroxamic derivatives ofstearic, palmitic and caprilic acids on 5-lipoxygenase from potato tubers. Their effects depended on pli and substrate concentrations and were independent - on time of incubation of enzyme with inhibitor. Hydroxamic derivative of stearic acid was the most effective inhibitor among investigated compounds. Sliortening of fatty acid side chain lead to sharp decreasing of inhibitory effect.

Original language	English (US)
Pages (from-to)	29-33
Number of pages	5
Journal	Biopolymers and Cell
Volume	12
Issue number	2
DOIs	https://doi.org/10.7124/bc.00041D
State	Published - 1996

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "In experiments in vitro were established inhibitory effects ofhydroxamic derivatives ofstearic, palmitic and caprilic acids on 5-lipoxygenase from potato tubers. Their effects depended on pli and substrate concentrations and were independent - on time of incubation of enzyme with inhibitor. Hydroxamic derivative of stearic acid was the most effective inhibitor among investigated compounds. Sliortening of fatty acid side chain lead to sharp decreasing of inhibitory effect.",

author = "Bondarenko, {L. V.} and Ohiy, {S. A.} and Tsernjuk, {V. N.} and Butovich, {I. A.}",

year = "1996",

doi = "10.7124/bc.00041D",

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AU - Bondarenko, L. V.

AU - Ohiy, S. A.

AU - Tsernjuk, V. N.

AU - Butovich, I. A.

PY - 1996

Y1 - 1996

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AB - In experiments in vitro were established inhibitory effects ofhydroxamic derivatives ofstearic, palmitic and caprilic acids on 5-lipoxygenase from potato tubers. Their effects depended on pli and substrate concentrations and were independent - on time of incubation of enzyme with inhibitor. Hydroxamic derivative of stearic acid was the most effective inhibitor among investigated compounds. Sliortening of fatty acid side chain lead to sharp decreasing of inhibitory effect.

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ER -

Hydroxamic derivatives of saturated fatty acids as inhibitors of 5-lipoxygenase

Abstract

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