Hybrid resistance: ‗Negative‘ and ‗positive‘ signaling of murine natural killer cells

Michael Bennett; Y. Y Lawrence Yu; Earl Stoneman; Richard M. Rembecki; Porunelloor A. Mathew; Kirsten Fischer Lindahl; Vinay Kumar

doi:10.1006/smim.1995.0016

Hybrid resistance: ‗Negative‘ and ‗positive‘ signaling of murine natural killer cells

Michael Bennett, Y. Y Lawrence Yu, Earl Stoneman, Richard M. Rembecki, Porunelloor A. Mathew, Kirsten Fischer Lindahl, Vinay Kumar

Immunology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Murine NK cells can reject allogenic or parental-strain bone marrow cells (BMC) in vivo and can lyse T lymphobasts in vitro. The ‗missing self‘ hypothesis states that absence or presence of ‗negative signals‘ from target cell class I antigens (Ag) to NK receptors determines whether or not lysis occurs. Indeed, lysis of parental-strain basts by purified F1 NK cell subsets occurred only in the presence of anti-receptor antibodies. Evidence for ‗positive signaling‘ to NK cells by class I Ag indudes rejection of D8 (D^d) transgene to B6) BMC by B6 hosts. The outcome of other BMC transplants ccntradict the missing self idea, because donors with identical class I Ag differ in compatibility with certain hosts. Perhaps class I Ag-NK cell receptor interactions dominate over other target-NK cell interactions. These interactions are usually ‗negative‘ but can be ‗positive‘.

Original language	English (US)
Pages (from-to)	121-127
Number of pages	7
Journal	Seminars in Immunology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1006/smim.1995.0016
State	Published - 1995

Keywords

Class I molecules
Lysis of lymphoblasts
Marrow grafts
NK receptors

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1006/smim.1995.0016

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@article{d53dcbf655024414abd56bc0f964ec31,

title = "Hybrid resistance: ‗Negative{\textquoteleft} and ‗positive{\textquoteleft} signaling of murine natural killer cells",

abstract = "Murine NK cells can reject allogenic or parental-strain bone marrow cells (BMC) in vivo and can lyse T lymphobasts in vitro. The ‗missing self{\textquoteleft} hypothesis states that absence or presence of ‗negative signals{\textquoteleft} from target cell class I antigens (Ag) to NK receptors determines whether or not lysis occurs. Indeed, lysis of parental-strain basts by purified F1 NK cell subsets occurred only in the presence of anti-receptor antibodies. Evidence for ‗positive signaling{\textquoteleft} to NK cells by class I Ag indudes rejection of D8 (Dd) transgene to B6) BMC by B6 hosts. The outcome of other BMC transplants ccntradict the missing self idea, because donors with identical class I Ag differ in compatibility with certain hosts. Perhaps class I Ag-NK cell receptor interactions dominate over other target-NK cell interactions. These interactions are usually ‗negative{\textquoteleft} but can be ‗positive{\textquoteleft}.",

keywords = "Class I molecules, Lysis of lymphoblasts, Marrow grafts, NK receptors",

author = "Michael Bennett and Yu, {Y. Y Lawrence} and Earl Stoneman and Rembecki, {Richard M.} and Mathew, {Porunelloor A.} and Lindahl, {Kirsten Fischer} and Vinay Kumar",

note = "Funding Information: This work was supported by grants CA36922, CA36921, CA09082 and AI35401 from the National Institutes of Health and a grant from the Texas Department of Ladies Auxiliary, Veterans of Foreign Wars. We thank our colleagues Chella David, Michael J. Siciliano, Edward Wake-land, Carla Aldrich, Bruce Blazar, Lorraine Flaherty, James Forman, Katharina C. Bl{\"o}mer, Thomas D{\textquoteright}Orazio and David Stenoien for participation in some of the studies described, and we thank Silvio and Maria Pe{\~n}a, Margaretan Stolfo, Henry Taylor and Annie Eubanks for excellent breeding and caring of mice used in these experiments.",

year = "1995",

doi = "10.1006/smim.1995.0016",

language = "English (US)",

volume = "7",

pages = "121--127",

journal = "Seminars in Immunology",

issn = "1044-5323",

publisher = "Academic Press Inc.",

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T1 - Hybrid resistance

T2 - ‗Negative‘ and ‗positive‘ signaling of murine natural killer cells

AU - Bennett, Michael

AU - Yu, Y. Y Lawrence

AU - Stoneman, Earl

AU - Rembecki, Richard M.

AU - Mathew, Porunelloor A.

AU - Lindahl, Kirsten Fischer

AU - Kumar, Vinay

N1 - Funding Information: This work was supported by grants CA36922, CA36921, CA09082 and AI35401 from the National Institutes of Health and a grant from the Texas Department of Ladies Auxiliary, Veterans of Foreign Wars. We thank our colleagues Chella David, Michael J. Siciliano, Edward Wake-land, Carla Aldrich, Bruce Blazar, Lorraine Flaherty, James Forman, Katharina C. Blömer, Thomas D’Orazio and David Stenoien for participation in some of the studies described, and we thank Silvio and Maria Peña, Margaretan Stolfo, Henry Taylor and Annie Eubanks for excellent breeding and caring of mice used in these experiments.

PY - 1995

Y1 - 1995

N2 - Murine NK cells can reject allogenic or parental-strain bone marrow cells (BMC) in vivo and can lyse T lymphobasts in vitro. The ‗missing self‘ hypothesis states that absence or presence of ‗negative signals‘ from target cell class I antigens (Ag) to NK receptors determines whether or not lysis occurs. Indeed, lysis of parental-strain basts by purified F1 NK cell subsets occurred only in the presence of anti-receptor antibodies. Evidence for ‗positive signaling‘ to NK cells by class I Ag indudes rejection of D8 (Dd) transgene to B6) BMC by B6 hosts. The outcome of other BMC transplants ccntradict the missing self idea, because donors with identical class I Ag differ in compatibility with certain hosts. Perhaps class I Ag-NK cell receptor interactions dominate over other target-NK cell interactions. These interactions are usually ‗negative‘ but can be ‗positive‘.

AB - Murine NK cells can reject allogenic or parental-strain bone marrow cells (BMC) in vivo and can lyse T lymphobasts in vitro. The ‗missing self‘ hypothesis states that absence or presence of ‗negative signals‘ from target cell class I antigens (Ag) to NK receptors determines whether or not lysis occurs. Indeed, lysis of parental-strain basts by purified F1 NK cell subsets occurred only in the presence of anti-receptor antibodies. Evidence for ‗positive signaling‘ to NK cells by class I Ag indudes rejection of D8 (Dd) transgene to B6) BMC by B6 hosts. The outcome of other BMC transplants ccntradict the missing self idea, because donors with identical class I Ag differ in compatibility with certain hosts. Perhaps class I Ag-NK cell receptor interactions dominate over other target-NK cell interactions. These interactions are usually ‗negative‘ but can be ‗positive‘.

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Hybrid resistance: ‗Negative‘ and ‗positive‘ signaling of murine natural killer cells

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