Hybrid resistance: ‗Negative‘ and ‗positive‘ signaling of murine natural killer cells

Michael Bennett, Y. Y Lawrence Yu, Earl Stoneman, Richard M. Rembecki, Porunelloor A. Mathew, Kirsten Fischer Lindahl, Vinay Kumar

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Murine NK cells can reject allogenic or parental-strain bone marrow cells (BMC) in vivo and can lyse T lymphobasts in vitro. The ‗missing self‘ hypothesis states that absence or presence of ‗negative signals‘ from target cell class I antigens (Ag) to NK receptors determines whether or not lysis occurs. Indeed, lysis of parental-strain basts by purified F1 NK cell subsets occurred only in the presence of anti-receptor antibodies. Evidence for ‗positive signaling‘ to NK cells by class I Ag indudes rejection of D8 (Dd) transgene to B6) BMC by B6 hosts. The outcome of other BMC transplants ccntradict the missing self idea, because donors with identical class I Ag differ in compatibility with certain hosts. Perhaps class I Ag-NK cell receptor interactions dominate over other target-NK cell interactions. These interactions are usually ‗negative‘ but can be ‗positive‘.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalSeminars in Immunology
Issue number2
StatePublished - 1995


  • Class I molecules
  • Lysis of lymphoblasts
  • Marrow grafts
  • NK receptors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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