Abstract
Sarcoidosis and Crohns disease have been associated with increased long term risk of lymphoproliferative disorders, including lymphomas. Newly developed lymphadenopathy in a patient with these disorders should prompt pathological evaluation. Castleman’s disease is a lymphoproliferative disorder characterized by enlarged hyperplastic lymph nodes with regressed follicles surrounded by expanded mantle zones of small lymphocytes, and interfollicular vascular proliferation in the hyaline-vascular type. Similar to sarcoidosis and Crohns disease, its etiology is incompletely understood, although immune dysregulation, genetic factors and infectious and environmental factors are thought to play a role in all three diseases. Interleukin-6 is a possible pathological common factor between these three disease processed. Unicentric, hyaline-vascular type Castleman’s disease can be treated successfully with complete surgical resection. We report a patient with long history of sarcoidosis and Crohns disease with newly developed lymphadenopathy which was found to be due to Castleman’s disease.
Original language | English (US) |
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Pages (from-to) | 335-339 |
Number of pages | 5 |
Journal | Indian Journal of Hematology and Blood Transfusion |
Volume | 32 |
DOIs | |
State | Published - Jun 1 2016 |
Keywords
- Castleman’s disease
- Crohns disease
- Sarcoidosis
- Surgical resection
ASJC Scopus subject areas
- Hematology