TY - JOUR
T1 - Human ovarian tissue cortex surrounding benign and malignant lesions
AU - Pavone, Mary Ellen
AU - Hirshfeld-Cytron, Jennifer
AU - Tingen, Candace
AU - Thomas, Cristina
AU - Thomas, Jessina
AU - Lowe, M. Patrick
AU - Schink, Julian C.
AU - Woodruff, Teresa K.
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: Supported by K12HD050121 , ASRM career development award (to MEP ), and U54 HD076188 (to TKW ).
PY - 2014/5
Y1 - 2014/5
N2 - Objective: To quantify the number of follicles in patients with ovarian pathologies, benign and malignant, in pregnant and nonpregnant states and to determine how the presence of ovarian masses and BRCA status affects follicular counts. Materials and Methods: Slides from 134 reproductive-aged women undergoing oophorectomy were examined using light microscopy by 3 independent counters blinded to the diagnosis. In all, 20 patients had cancer, 69 had benign conditions, and 35 patients were BRCA or had a strong family history of breast and/or ovarian cancer. In all, 10 women were either pregnant or immediately postpartum. Results: Patients undergoing risk-reducing surgery had significantly decreased follicle count compared to physiologic control. Patients with cancer had significantly decreased counts compared to all other groups. There were no differences within the benign cohort. Conclusions: When compared to benign masses, the cortex surrounding an ovarian malignancy has decreased follicle density. The stretch impact may minimize any impact on total follicle numbers. Furthermore, there may be a proliferation of ovarian stroma, with the same number of follicles spread over a larger surface area. This information is important when counseling women with ovarian masses regarding the use of ovarian tissue cryopreservation.
AB - Objective: To quantify the number of follicles in patients with ovarian pathologies, benign and malignant, in pregnant and nonpregnant states and to determine how the presence of ovarian masses and BRCA status affects follicular counts. Materials and Methods: Slides from 134 reproductive-aged women undergoing oophorectomy were examined using light microscopy by 3 independent counters blinded to the diagnosis. In all, 20 patients had cancer, 69 had benign conditions, and 35 patients were BRCA or had a strong family history of breast and/or ovarian cancer. In all, 10 women were either pregnant or immediately postpartum. Results: Patients undergoing risk-reducing surgery had significantly decreased follicle count compared to physiologic control. Patients with cancer had significantly decreased counts compared to all other groups. There were no differences within the benign cohort. Conclusions: When compared to benign masses, the cortex surrounding an ovarian malignancy has decreased follicle density. The stretch impact may minimize any impact on total follicle numbers. Furthermore, there may be a proliferation of ovarian stroma, with the same number of follicles spread over a larger surface area. This information is important when counseling women with ovarian masses regarding the use of ovarian tissue cryopreservation.
KW - endometriosis
KW - fertility preservation
KW - follicle density
KW - ovarian cancer
KW - ovarian tissue cryopreservation
KW - ovarian tissue transplantation
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U2 - 10.1177/1933719113506498
DO - 10.1177/1933719113506498
M3 - Article
C2 - 24096576
AN - SCOPUS:84898930008
SN - 1933-7191
VL - 21
SP - 582
EP - 589
JO - Reproductive Sciences
JF - Reproductive Sciences
IS - 5
ER -