TY - JOUR
T1 - Human natural killer cells enhance a mixed leukocyte reaction
AU - Weissler, J. C.
AU - Yarbrough, W. C.
AU - Toews, G. B.
AU - Nicod, L. P.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1988
Y1 - 1988
N2 - Natural killer cells (NK) have been reported to down-regulate the initiation of T cell responses in animal models. In the current study, highly purified CD16+ human NK cells were obtained by cell sorting and their effect on the stimulation of allogeneic T cells (MLR) determined. NK cells did not directly stimulate T cell proliferation. However, when added to a population of loosely adherent mononuclear cells (LAM), NK enhanced the ability of these accessory cells to stimulate T proliferation. This effect was not reproduced by the addition of sorted CD5+ T cells, sorted CD16- cells, or control lymphocytes to the MLR. The effect of NK on the MLR was not restricted by class II antigens and was similar to the effect of adding IL-1 to MLR cultures. These results demonstrate that human NK cells are capable of enhancing a T cell response.
AB - Natural killer cells (NK) have been reported to down-regulate the initiation of T cell responses in animal models. In the current study, highly purified CD16+ human NK cells were obtained by cell sorting and their effect on the stimulation of allogeneic T cells (MLR) determined. NK cells did not directly stimulate T cell proliferation. However, when added to a population of loosely adherent mononuclear cells (LAM), NK enhanced the ability of these accessory cells to stimulate T proliferation. This effect was not reproduced by the addition of sorted CD5+ T cells, sorted CD16- cells, or control lymphocytes to the MLR. The effect of NK on the MLR was not restricted by class II antigens and was similar to the effect of adding IL-1 to MLR cultures. These results demonstrate that human NK cells are capable of enhancing a T cell response.
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U2 - 10.1002/jlb.43.4.291
DO - 10.1002/jlb.43.4.291
M3 - Article
C2 - 2965195
AN - SCOPUS:0023919093
SN - 0741-5400
VL - 43
SP - 291
EP - 298
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
IS - 4
ER -