Human herpesvirus 1 UL24 gene encodes a potential PD-(D/E)XK endonuclease

Łukasz Knizewski, Lisa Kinch, Nick V. Grishin, Leszek Rychlewski, Krzysztof Ginalski

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Using Meta-BASIC, a highly sensitive method for detection of distant similarity between proteins, we have identified another potential PD-(D/E)XK endonuclease in human herpesvirus 1 (HHV-1) encoded by the UL24 gene. The universal presence of UL24 in completed herpesviral genomes of three major subfamilies, Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae, suggests a fundamental role for this predicted PD-(D/E)XK endonuclease activity in the viral life cycle.

Original languageEnglish (US)
Pages (from-to)2575-2577
Number of pages3
JournalJournal of virology
Issue number5
StatePublished - Mar 2006

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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