Human cytochromes P450

Julia A. Hasler; Ronald Estabrook; Michael Murray; Irina Pikuleva; Michael Waterman; Jorge Capdevila; Vijakumar Holla; Christian Helvig; J R Falck; Geoffrey Farrell; Laurence S. Kaminsky; Simon D. Spivack; Eric Boitier; Philippe Beaune

doi:10.1016/S0098-2997(99)00005-9

Human cytochromes P450

Julia A. Hasler, Ronald Estabrook, Michael Murray, Irina Pikuleva, Michael Waterman, Jorge Capdevila, Vijakumar Holla, Christian Helvig, J R Falck, Geoffrey Farrell, Laurence S. Kaminsky, Simon D. Spivack, Eric Boitier, Philippe Beaune

Biochemistry

Research output: Contribution to journal › Review article › peer-review

156 Scopus citations

Abstract

The cytochrome P450 proteins (CYPs) are a family of haem proteins resulting from expression of a gene super-family that currently contains around 1000 members in species ranging from bacteria through to plants and animals. In humans, about 40 different CYPs are present and these play critical roles by catalyzing reactions in: (a) the metabolism of drugs, environmental pollutants and other xenobiotics; (b) the biosynthesis of steroid hormones; (c) the oxidation of unsaturated fatty acids to intracellular messengers; and (d) the stereo- and regio-specific metabolism of fat-soluble vitamins. This review deals with aspects of cytochrome P450s of relevance to human physiology, biochemistry, pharmacology and medicine. Topics reviewed include: pharmacogenetics of CYPs, induction and inhibition of these haem proteins, their role in metabolism of endogenous compounds such as steroids and eicosanoids, the effect of disease on CYP function, CYPs and cancer, and CYPs as targets of antibodies in immune-mediated diseases. Copyright (C) 1999 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	1-137
Number of pages	137
Journal	Molecular aspects of medicine
Volume	20
Issue number	1-2
DOIs	https://doi.org/10.1016/S0098-2997(99)00005-9
State	Published - Feb 1999

Keywords

Autoantibodies
Cancer
Chemical carcinogenesis
Cytochrome P450
Disease
Drug metabolism
Eicosaniod metabolism
Fatty acid epoxidation
Genetic polymorphisms
Steroid hormone synthesis
Xenobiotics

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry

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10.1016/S0098-2997(99)00005-9

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title = "Human cytochromes P450",

abstract = "The cytochrome P450 proteins (CYPs) are a family of haem proteins resulting from expression of a gene super-family that currently contains around 1000 members in species ranging from bacteria through to plants and animals. In humans, about 40 different CYPs are present and these play critical roles by catalyzing reactions in: (a) the metabolism of drugs, environmental pollutants and other xenobiotics; (b) the biosynthesis of steroid hormones; (c) the oxidation of unsaturated fatty acids to intracellular messengers; and (d) the stereo- and regio-specific metabolism of fat-soluble vitamins. This review deals with aspects of cytochrome P450s of relevance to human physiology, biochemistry, pharmacology and medicine. Topics reviewed include: pharmacogenetics of CYPs, induction and inhibition of these haem proteins, their role in metabolism of endogenous compounds such as steroids and eicosanoids, the effect of disease on CYP function, CYPs and cancer, and CYPs as targets of antibodies in immune-mediated diseases. Copyright (C) 1999 Elsevier Science Ltd.",

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author = "Hasler, {Julia A.} and Ronald Estabrook and Michael Murray and Irina Pikuleva and Michael Waterman and Jorge Capdevila and Vijakumar Holla and Christian Helvig and Falck, {J R} and Geoffrey Farrell and Kaminsky, {Laurence S.} and Spivack, {Simon D.} and Eric Boitier and Philippe Beaune",

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AU - Hasler, Julia A.

AU - Estabrook, Ronald

AU - Murray, Michael

AU - Pikuleva, Irina

AU - Waterman, Michael

AU - Capdevila, Jorge

AU - Holla, Vijakumar

AU - Helvig, Christian

AU - Falck, J R

AU - Farrell, Geoffrey

AU - Kaminsky, Laurence S.

AU - Spivack, Simon D.

AU - Boitier, Eric

AU - Beaune, Philippe

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AB - The cytochrome P450 proteins (CYPs) are a family of haem proteins resulting from expression of a gene super-family that currently contains around 1000 members in species ranging from bacteria through to plants and animals. In humans, about 40 different CYPs are present and these play critical roles by catalyzing reactions in: (a) the metabolism of drugs, environmental pollutants and other xenobiotics; (b) the biosynthesis of steroid hormones; (c) the oxidation of unsaturated fatty acids to intracellular messengers; and (d) the stereo- and regio-specific metabolism of fat-soluble vitamins. This review deals with aspects of cytochrome P450s of relevance to human physiology, biochemistry, pharmacology and medicine. Topics reviewed include: pharmacogenetics of CYPs, induction and inhibition of these haem proteins, their role in metabolism of endogenous compounds such as steroids and eicosanoids, the effect of disease on CYP function, CYPs and cancer, and CYPs as targets of antibodies in immune-mediated diseases. Copyright (C) 1999 Elsevier Science Ltd.

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KW - Cancer

KW - Chemical carcinogenesis

KW - Cytochrome P450

KW - Disease

KW - Drug metabolism

KW - Eicosaniod metabolism

KW - Fatty acid epoxidation

KW - Genetic polymorphisms

KW - Steroid hormone synthesis

KW - Xenobiotics

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Human cytochromes P450

Abstract

Keywords

ASJC Scopus subject areas

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