TY - JOUR
T1 - HPLC Analysis of 6-Mercaptopurine and Metabolites in Extracellular Body Fluids
AU - Rudy, J. L.
AU - Argyle, J. C.
AU - Winick, N.
AU - Van Dreal, P.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1988/9
Y1 - 1988/9
N2 - A convenient HPLC assay, which allows for the simultaneous measurement in extracellular fluids of 6-mercaptopurine and four of its metabolites, 6-thioguanine, 6-mercaptopurine riboside, 6-thioxanthine and 6-thiouric acid is described. Solid phase extraction allows for the clean isolation of analytes from plasma, urine or cerebrospinal fluid. The simultaneous determination of 6-mercaptopurine and some of its major metabolites in extracellular fluids may contribute to the monitoring of patient compliance, bioavailability, and individual variation in metabolism and absorption.
AB - A convenient HPLC assay, which allows for the simultaneous measurement in extracellular fluids of 6-mercaptopurine and four of its metabolites, 6-thioguanine, 6-mercaptopurine riboside, 6-thioxanthine and 6-thiouric acid is described. Solid phase extraction allows for the clean isolation of analytes from plasma, urine or cerebrospinal fluid. The simultaneous determination of 6-mercaptopurine and some of its major metabolites in extracellular fluids may contribute to the monitoring of patient compliance, bioavailability, and individual variation in metabolism and absorption.
UR - http://www.scopus.com/inward/record.url?scp=0023791218&partnerID=8YFLogxK
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U2 - 10.1177/000456328802500505
DO - 10.1177/000456328802500505
M3 - Article
C2 - 3232952
AN - SCOPUS:0023791218
SN - 0004-5632
VL - 25
SP - 504
EP - 509
JO - Annals of Clinical Biochemistry
JF - Annals of Clinical Biochemistry
IS - 5
ER -