How obesity causes diabetes in Zucker diabetic fatty rats

Roger H Unger

Research output: Contribution to journalReview articlepeer-review

103 Scopus citations


The mechanisms of adipogenic diabetes in Zucker diabetic fatty (ZDF) rats, a model of obesity complicated by diabetes, are reviewed. In ZDF rats, a mutation in the leptin receptor, OB-R, is associated with leptin resistance, obesity, and increased fat content of islets. Exaggerated nitric oxide (NO) generation, attributed to high intracellular levels of long-chain fatty acids, impairs β-cell function and prevents their compensation for obesity-induced diabetes. The resulting diabetic hyperglycemia can be completely prevented by agents that inhibit NO production.

Original languageEnglish (US)
Pages (from-to)276-282
Number of pages7
JournalTrends in Endocrinology and Metabolism
Issue number7
StatePublished - Sep 1 1997

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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