How NPC1 Loss Twists the TORCque of Lysosomes

Research output: Contribution to journalArticlepeer-review


Niemann-Pick type C is a neurological disorder caused by mutations in the lysosome cholesterol exporter NPC1. In this issue of Developmental Cell, Davis et al. dissect how NPC1 loss elevates mTORC1 signaling, and demonstrate that suppression of mTORC1 signaling can rescue disease pathology in NPC1-deficient cell models.

Original languageEnglish (US)
Pages (from-to)251-252
Number of pages2
JournalDevelopmental cell
Issue number3
StatePublished - Feb 8 2021

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology


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