How NPC1 Loss Twists the TORCque of Lysosomes

W. Mike Henne

doi:10.1016/j.devcel.2021.01.007

How NPC1 Loss Twists the TORCque of Lysosomes

Research output: Contribution to journal › Article › peer-review

Abstract

Niemann-Pick type C is a neurological disorder caused by mutations in the lysosome cholesterol exporter NPC1. In this issue of Developmental Cell, Davis et al. dissect how NPC1 loss elevates mTORC1 signaling, and demonstrate that suppression of mTORC1 signaling can rescue disease pathology in NPC1-deficient cell models.

Original language	English (US)
Pages (from-to)	251-252
Number of pages	2
Journal	Developmental cell
Volume	56
Issue number	3
DOIs	https://doi.org/10.1016/j.devcel.2021.01.007
State	Published - Feb 8 2021

ASJC Scopus subject areas

Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Developmental Biology
Cell Biology

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10.1016/j.devcel.2021.01.007

Cite this

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abstract = "Niemann-Pick type C is a neurological disorder caused by mutations in the lysosome cholesterol exporter NPC1. In this issue of Developmental Cell, Davis et al. dissect how NPC1 loss elevates mTORC1 signaling, and demonstrate that suppression of mTORC1 signaling can rescue disease pathology in NPC1-deficient cell models.",

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How NPC1 Loss Twists the TORCque of Lysosomes

Abstract

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