How much can SNAREs flex their muscles?

Jose Rizo-Rey, Han Dai

Research output: Contribution to journalShort surveypeer-review

5 Scopus citations


The high stability of SNARE complexes is probably crucial for their role in membrane fusion, but it has been difficult to measure. A surface-forces apparatus has now been used to measure the stabilization energy of a partially assembled SNARE complex, and the result (35 kBT) is among the highest protein-folding free energies ever observed. Moreover, this approach offers a bright future for further structural and energetic studies of membrane fusion machineries.

Original languageEnglish (US)
Pages (from-to)880-882
Number of pages3
JournalNature Structural and Molecular Biology
Issue number10
StatePublished - Oct 1 2007

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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