Abstract
The high stability of SNARE complexes is probably crucial for their role in membrane fusion, but it has been difficult to measure. A surface-forces apparatus has now been used to measure the stabilization energy of a partially assembled SNARE complex, and the result (35 kBT) is among the highest protein-folding free energies ever observed. Moreover, this approach offers a bright future for further structural and energetic studies of membrane fusion machineries.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 880-882 |
| Number of pages | 3 |
| Journal | Nature Structural and Molecular Biology |
| Volume | 14 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2007 |
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology