TY - JOUR
T1 - Host-microbial symbiosis in the mammalian intestine
T2 - Exploring an internal ecosystem
AU - Hooper, Lora V.
AU - Bry, Lynn
AU - Falk, Per G.
AU - Gordon, Jeffrey I.
PY - 1998/4
Y1 - 1998/4
N2 - The mammalian intestine contains a complex, dynamic, and spatially diversified society of nonpathogenic bacteria. Very little is known about the factors that help establish host-microbial symbiosis in this open ecosystem. By introducing single genetically manipulatable components of the microflora into germfree mice, simplified model systems have been created that will allow conversations between host and microbe to be heard and understood. Other paradigms of host-microbial symbiosis suggest that these interactions will involve an exchange of biochemical signals between host and symbionts as well as among the bacteria themselves. The integration of molecular microbiology, cell biology, and gnotobiology should provide new insights about how we adapt to a microbial world and reveal the roles played by our indigenous 'nonpathogenic' flora.
AB - The mammalian intestine contains a complex, dynamic, and spatially diversified society of nonpathogenic bacteria. Very little is known about the factors that help establish host-microbial symbiosis in this open ecosystem. By introducing single genetically manipulatable components of the microflora into germfree mice, simplified model systems have been created that will allow conversations between host and microbe to be heard and understood. Other paradigms of host-microbial symbiosis suggest that these interactions will involve an exchange of biochemical signals between host and symbionts as well as among the bacteria themselves. The integration of molecular microbiology, cell biology, and gnotobiology should provide new insights about how we adapt to a microbial world and reveal the roles played by our indigenous 'nonpathogenic' flora.
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U2 - 10.1002/(SICI)1521-1878(199804)20:4<336::AID-BIES10>3.0.CO;2-3
DO - 10.1002/(SICI)1521-1878(199804)20:4<336::AID-BIES10>3.0.CO;2-3
M3 - Article
C2 - 9619105
AN - SCOPUS:0032054355
SN - 0265-9247
VL - 20
SP - 336
EP - 343
JO - BioEssays
JF - BioEssays
IS - 4
ER -