Host-microbe interaction systems biology: Lifecycle transcriptomics and comparative genomics

Daniel E. Sturdevant; Kimmo Virtaneva; Craig Martens; Daniel Bozinov; Olajumoke Ogundare; Nina Castro; Kishore Kanakabandi; Paul A. Beare; Anders Omsland; John H. Carlson; Adam D. Kennedy; Robert A. Heinzen; Jean Celli; David E. Greenberg; Frank R. Deleo; Stephen F. Porcella

doi:10.2217/fmb.09.125

Host-microbe interaction systems biology: Lifecycle transcriptomics and comparative genomics

Daniel E. Sturdevant, Kimmo Virtaneva, Craig Martens, Daniel Bozinov, Olajumoke Ogundare, Nina Castro, Kishore Kanakabandi, Paul A. Beare, Anders Omsland, John H. Carlson, Adam D. Kennedy, Robert A. Heinzen, Jean Celli, David E. Greenberg, Frank R. Deleo, Stephen F. Porcella

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

The use of microarray and comparative genomic technologies for the analysis of host-pathogen interactions has led to a greater understanding of the biological systems involved in infectious disease processes. Transcriptome analysis of intracellular pathogens at single or multiple time points during infection offers insight into the pathogen intracellular lifecycle. Host-pathogen transcriptome analysis in vivo, over time, enables characterization of both the pathogen and the host during the dynamic, multicellular host response. Comparative genomics using hybridization microarray-based comparative whole-genome resequencing or de novo whole-genome sequencing can identify the genetic factors responsible for pathogen evolutionary divergence, emergence, reemergence or the genetic basis for different pathogenic phenotypes. Together, microarray and comparative genomic technologies will continue to advance our understanding of pathogen evolution and assist in combating human infectious disease.

Original language	English (US)
Pages (from-to)	205-219
Number of pages	15
Journal	Future Microbiology
Volume	5
Issue number	2
DOIs	https://doi.org/10.2217/fmb.09.125
State	Published - Feb 2010

Keywords

Genomics
Host
Microarray
Microbe

ASJC Scopus subject areas

Microbiology
Microbiology (medical)

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10.2217/fmb.09.125

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Sturdevant, D. E., Virtaneva, K., Martens, C., Bozinov, D., Ogundare, O., Castro, N., Kanakabandi, K., Beare, P. A., Omsland, A., Carlson, J. H., Kennedy, A. D., Heinzen, R. A., Celli, J., Greenberg, D. E., Deleo, F. R., & Porcella, S. F. (2010). Host-microbe interaction systems biology: Lifecycle transcriptomics and comparative genomics. Future Microbiology, 5(2), 205-219. https://doi.org/10.2217/fmb.09.125

Sturdevant, DE, Virtaneva, K, Martens, C, Bozinov, D, Ogundare, O, Castro, N, Kanakabandi, K, Beare, PA, Omsland, A, Carlson, JH, Kennedy, AD, Heinzen, RA, Celli, J, Greenberg, DE, Deleo, FR & Porcella, SF 2010, 'Host-microbe interaction systems biology: Lifecycle transcriptomics and comparative genomics', Future Microbiology, vol. 5, no. 2, pp. 205-219. https://doi.org/10.2217/fmb.09.125

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doi = "10.2217/fmb.09.125",

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AU - Kennedy, Adam D.

AU - Heinzen, Robert A.

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Host-microbe interaction systems biology: Lifecycle transcriptomics and comparative genomics

Abstract

Keywords

ASJC Scopus subject areas

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