Maturity-onset diabetes of the young (MODY) is a rare subtype of type 2 diabetes that is characterized by autosomal-dominant inheritance and can be caused by mutations in hepatocyte nuclear factor 4α (HNF-4α). Odom and colleagues have combined chromatin immunoprecipitation with promoter microarrays to identify numerous promoters occupied by HNF-4α in the human liver and islet, suggesting a very broad role for HNF-4α in glucose homeostasis. This notion is supported by recent genetic studies linking HNF-4α to the much more common late-onset type 2 diabetes.
|Original language||English (US)|
|Number of pages||4|
|Journal||Trends in Molecular Medicine|
|State||Published - Nov 2004|
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology