TY - JOUR
T1 - HMT, encoded by H-2M3, is a neoclassical major histocompatibility class I antigen
AU - Wang, Chyung Ru
AU - Lindahl, Kirsten Fischer
PY - 1993/4/1
Y1 - 1993/4/1
N2 - H-2M3 encodes HMT, the major histocompatibility complex (MHC) class I heavy chain of the maternally transmitted antigen (Mta). Like classical MHC class I genes, the expression of M3 can be stimulated by γ-interferon and its message can be detected from mid-gestational embryos (day 8) through adulthood. HMTb, a nonimmunogenic allelic form of HMT, differs from the common HMTa molecule by four amino acids, of which only two (residues 31 and 95) are located in the α1 and α2 domains that form the peptide-binding groove. Recognition of site-directed mutants by Mta-specific cytotoxic T lymphocytes was hardly affected by the substitution of Met for Val31 but was abolished by the substitution of GIl for Leu95, which is located in the β-sheet floor of the peptide-binding groove. Thus a single amino acid difference is responsible for the immunological silence of HMTb.
AB - H-2M3 encodes HMT, the major histocompatibility complex (MHC) class I heavy chain of the maternally transmitted antigen (Mta). Like classical MHC class I genes, the expression of M3 can be stimulated by γ-interferon and its message can be detected from mid-gestational embryos (day 8) through adulthood. HMTb, a nonimmunogenic allelic form of HMT, differs from the common HMTa molecule by four amino acids, of which only two (residues 31 and 95) are located in the α1 and α2 domains that form the peptide-binding groove. Recognition of site-directed mutants by Mta-specific cytotoxic T lymphocytes was hardly affected by the substitution of Met for Val31 but was abolished by the substitution of GIl for Leu95, which is located in the β-sheet floor of the peptide-binding groove. Thus a single amino acid difference is responsible for the immunological silence of HMTb.
KW - Cytotoxic T lymphocytes
KW - Gene expression
KW - Interferon γ
KW - Peptide presentation
KW - Site-directed mutagenesis
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U2 - 10.1073/pnas.90.7.2784
DO - 10.1073/pnas.90.7.2784
M3 - Article
C2 - 8464890
AN - SCOPUS:0027406828
SN - 0027-8424
VL - 90
SP - 2784
EP - 2788
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 7
ER -