Abstract
The HLA-A, B, C, DR and DQ antigens were determined in 50 Singapore Chinese patients with rheumatoid arthritis (RA). There was a significant increase in the prevalence of HLA-Bw46, DRw53 and DQ3 in patients with RA. The linkage disequilibrium between Bw46 and DRw53 explains this association. This major histocompatibility complex association differs from the HLA-DR4 link in Caucasian populations and suggests that RA is an immunogenetically heterogeneous disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1517-1519 |
| Number of pages | 3 |
| Journal | Journal of Rheumatology |
| Volume | 19 |
| Issue number | 10 |
| State | Published - Jan 1 1992 |
Keywords
- Chinese
- HLA
- rheumatoid arthritis
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology