HLA Dw4 in adult and juvenile rheumatoid arthritis

P. Stastny, C. W. Fink

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


HLA-D typing using homozygous typing cells (HTC) has shown a marked increase in HLA-Dw4 in adult patients with rheumatoid arthritis (RA). In an earlier study, Dw4 was found in 48% of patients and 8% of controls. In the present series, the frequencies are 59% and 16%, respectively. HLA-Dw4 does not appear to be increased in two small groups of non-white patients (black and Mexican-American). It also was not found to be increased in children with juvenile RA or in any of the three clinical subgroups of this disease. Another determinant, LD-TMo, was increased in arthritis developing in children. Thus, different immunogenetic factors appear to characterize clinically distinguishable forms of arthritis. The basis for these different HLA-D associations is presently unknown.

Original languageEnglish (US)
Pages (from-to)1863-1866
Number of pages4
JournalTransplantation Proceedings
Issue number4
StatePublished - Dec 1 1977

ASJC Scopus subject areas

  • Surgery
  • Transplantation


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