Abstract
HIV-1 transcription is regulated at the level of elongation by the viral Tat protein together with the cellular elongation factor P-TEFb, which is composed of cyclin T1 and Cdk9 subunits. The crystal structure of a Tat: P-TEFb complex (Tahirov, T.H.; Babayeva, N.D.; Varzavand, K.; Cooper, J.J.; Sedore, S.C.; and Price, D.H. Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature 2010, 465, 747-751.) reveals molecular details of Tat and its interactions that have eluded investigators for more than two decades and provides provocative insights into the mechanism of Tat activation.
Original language | English (US) |
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Pages (from-to) | 2226-2234 |
Number of pages | 9 |
Journal | Viruses |
Volume | 2 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2010 |
Keywords
- HIV-1
- P-TEFB
- Retroviruses
- Tat
- Transcription
ASJC Scopus subject areas
- Infectious Diseases
- Virology