TY - JOUR
T1 - History, applications, and mechanisms of deep brain stimulation
AU - Miocinovic, Svjetlana
AU - Somayajula, Suvarchala
AU - Chitnis, Shilpa
AU - Vitek, Jerrold L.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2013/2
Y1 - 2013/2
N2 - Deep brain stimulation (DBS) is an effective surgical treatment for medication-refractory hypokinetic and hyperkinetic movement disorders, and it is being explored for a variety of other neurological and psychiatric diseases. Deep brain stimulation has been Food and Drug Administration-approved for essential tremor and Parkinson disease and has a humanitarian device exemption for dystonia and obsessive-compulsive disorder. Neurostimulation is the fruit of decades of both technical and scientific advances in the field of basic neuroscience and functional neurosurgery. Despite the clinical success of DBS, the therapeutic mechanism of DBS remains under debate. Our objective is to provide a comprehensive review of DBS focusing on movement disorders, including the historical evolution of the technique, applications and outcomes with an overview of the most pertinent literature, current views on mechanisms of stimulation, and description of hardware and programming techniques. We conclude with a discussion of future developments in neurostimulation.
AB - Deep brain stimulation (DBS) is an effective surgical treatment for medication-refractory hypokinetic and hyperkinetic movement disorders, and it is being explored for a variety of other neurological and psychiatric diseases. Deep brain stimulation has been Food and Drug Administration-approved for essential tremor and Parkinson disease and has a humanitarian device exemption for dystonia and obsessive-compulsive disorder. Neurostimulation is the fruit of decades of both technical and scientific advances in the field of basic neuroscience and functional neurosurgery. Despite the clinical success of DBS, the therapeutic mechanism of DBS remains under debate. Our objective is to provide a comprehensive review of DBS focusing on movement disorders, including the historical evolution of the technique, applications and outcomes with an overview of the most pertinent literature, current views on mechanisms of stimulation, and description of hardware and programming techniques. We conclude with a discussion of future developments in neurostimulation.
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U2 - 10.1001/2013.jamaneurol.45
DO - 10.1001/2013.jamaneurol.45
M3 - Review article
C2 - 23407652
AN - SCOPUS:84874062301
SN - 2168-6149
VL - 70
SP - 163
EP - 171
JO - JAMA neurology
JF - JAMA neurology
IS - 2
ER -