Histone phosphorylation during liver regeneration

William T. Garrard, George H. Kidd, James Bonner

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The pattern of histone phosphorylation at acid-stable, alkali-labile sites has been examined throughout the early stages of liver regeneration, namely at times of "gene activation". Among the histones, only H1 shows an increase in phosphorylation. This increase initiates near the end of the period of chromatin template activation. Thus, there is no obvious temporal correlation between increased histone phosphorylation and increased RNA synthesis. The relative levels of phosphorylation of the various histones and the change in H1 phosphorylation observed in the liver system closely parallel the patterns exhibited by cultured animal cells during the G1 and S phases of the cycle as described by other investigators.

Original languageEnglish (US)
Pages (from-to)1219-1224
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number4
StatePublished - Jun 21 1976

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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