Histologic transformation of EGFR mutant lung adenocarcinoma without exposure to EGFR inhibition

Tri Le; Joseph Sailors; Dwight H. Oliver; Melissa Mayer; Sharon Hoskin; David E. Gerber

doi:10.1016/j.lungcan.2017.01.005

Histologic transformation of EGFR mutant lung adenocarcinoma without exposure to EGFR inhibition

Tri Le, Joseph Sailors, Dwight H. Oliver, Melissa Mayer, Sharon Hoskin, David E. Gerber

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Resistance to EGFR kinase inhibitors appears to be invariable in the treatment of non-small cell lung cancer. Several mechanisms have been described. Here, we report the first case of histologic transformation of EGFR mutant lung adenocarcinoma without prior exposure to EGFR inhibition.

Original language	English (US)
Pages (from-to)	14-16
Number of pages	3
Journal	Lung Cancer
Volume	105
DOIs	https://doi.org/10.1016/j.lungcan.2017.01.005
State	Published - Mar 1 2017

Keywords

Adenocarcinoma NSCLC
EGFR
Squamous NSCLC

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

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10.1016/j.lungcan.2017.01.005

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title = "Histologic transformation of EGFR mutant lung adenocarcinoma without exposure to EGFR inhibition",

abstract = "Resistance to EGFR kinase inhibitors appears to be invariable in the treatment of non-small cell lung cancer. Several mechanisms have been described. Here, we report the first case of histologic transformation of EGFR mutant lung adenocarcinoma without prior exposure to EGFR inhibition.",

keywords = "Adenocarcinoma NSCLC, EGFR, Squamous NSCLC",

author = "Tri Le and Joseph Sailors and Oliver, {Dwight H.} and Melissa Mayer and Sharon Hoskin and Gerber, {David E.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2017",

month = mar,

day = "1",

doi = "10.1016/j.lungcan.2017.01.005",

language = "English (US)",

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T1 - Histologic transformation of EGFR mutant lung adenocarcinoma without exposure to EGFR inhibition

AU - Le, Tri

AU - Sailors, Joseph

AU - Oliver, Dwight H.

AU - Mayer, Melissa

AU - Hoskin, Sharon

AU - Gerber, David E.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Resistance to EGFR kinase inhibitors appears to be invariable in the treatment of non-small cell lung cancer. Several mechanisms have been described. Here, we report the first case of histologic transformation of EGFR mutant lung adenocarcinoma without prior exposure to EGFR inhibition.

AB - Resistance to EGFR kinase inhibitors appears to be invariable in the treatment of non-small cell lung cancer. Several mechanisms have been described. Here, we report the first case of histologic transformation of EGFR mutant lung adenocarcinoma without prior exposure to EGFR inhibition.

KW - Adenocarcinoma NSCLC

KW - EGFR

KW - Squamous NSCLC

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DO - 10.1016/j.lungcan.2017.01.005

M3 - Article

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AN - SCOPUS:85009385358

SN - 0169-5002

VL - 105

SP - 14

EP - 16

JO - Lung Cancer

JF - Lung Cancer

ER -

Histologic transformation of EGFR mutant lung adenocarcinoma without exposure to EGFR inhibition

Abstract

Keywords

ASJC Scopus subject areas

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