Hippocampal PER1: a circadian sentinel controlling RSKy activity during memory formation

Seung Hee Yoo, Kristin Eckel-Mahan

Research output: Contribution to journalEditorialpeer-review

4 Scopus citations


(Figure presented.) Studies have demonstrated a pronounced dependence of memory formation on circadian time; however, the numerous mechanisms underlying this reliance are only beginning to be understood. While the 24-h cellular clock controls various aspects of hippocampal memory formation, its consolidation in particular (i.e., its conversion from short-term to long-term memory), appears to be heavily dependent on circadian activity in hippocampal neurons. Hippocampal memory consolidation requires phosphorylation of the cAMP Response Element-Binding protein, CREB, which upon phosphorylation promotes the transcription of genes necessary for long-term memory formation. Rhythmic cAMP/ERK-MAPK activity upstream of CREB is a necessary component. This Editorial highlights a study by Rawashdeh and coworkers, in which the authors establish the circadian clock gene Period1 (Per1) as a regulator of CREB phosphorylation in the mouse hippocampus, and thus reveal a functional link between circadian rhythms and learning efficiency. Read the highlighted article ‘Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK’ on page 731.

Original languageEnglish (US)
Pages (from-to)650-652
Number of pages3
JournalJournal of Neurochemistry
StatePublished - Sep 1 2016

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Hippocampal PER1: a circadian sentinel controlling RSKy activity during memory formation'. Together they form a unique fingerprint.

Cite this