Hippocampal novelty activations in schizophrenia: Disease and medication effects

Carol A. Tamminga, Binu P. Thomas, Ronald Chin, Perry Mihalakos, Kenneth Youens, Anthony D. Wagner, Alison R. Preston

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


We examined hippocampal activation in schizophrenia (SZ) with fMRI BOLD in response to the presentation of novel and familiar scenes. Voxel-wise analysis showed no group differences. However, anatomical region-of-interest analyses contrasting normal (NL), SZ-on-medication (SZ-ON), SZ-off-medication (SZ-OFF) showed substantial differences in MTL-based novelty responding, accounted for by the reduction in novelty responses in the SZ-OFF predominantly in the anterior hippocampus and parahippocampal cortex. These differences in novelty-based activation in the SZ-OFF group represent disease characteristics of schizophrenia without confounding effects of antipsychotic medication and illustrate the tendency of antipsychotic drug treatment to improve memory functions in schizophrenia.

Original languageEnglish (US)
Pages (from-to)157-163
Number of pages7
JournalSchizophrenia Research
Issue number2-3
StatePublished - Jul 2012


  • Anti-psychotic drugs
  • Brain imaging
  • Declarative memory
  • Hippocampus
  • Psychosis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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