Hippocampal abnormalities in depression

K. R R Krishman; P. M. Doraiswamy; G. S. Figiel; M. M. Husain; S. A. Shah; C. Na; O. B. Boyko; W. M. McDonald; C. B. Nemeroff; E. H. Ellinwood

doi:10.1176/jnp.3.4.387

Hippocampal abnormalities in depression

K. R R Krishman, P. M. Doraiswamy, G. S. Figiel, M. M. Husain, S. A. Shah, C. Na, O. B. Boyko, W. M. McDonald, C. B. Nemeroff, E. H. Ellinwood

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Abstract

A quantitative magnetic resonance imaging study of regional brain T1 spin-lattice relaxation times in 29 normal volunteers and in 20 patients with major depression revealed significantly shortened T1 relaxation times for the hippocampus in depressed patients. These differences were particularly prominent in elderly depressed patients. T1 relaxation times are reflective of the content and macromolecular environment of tissue water protons; shorter hippocampal T1 values may reflect differences in the content or organizational properties of hippocampal water protons. These findings are consistent with several lines of evidence that have implicated a role for the hippocampus in the regulation of mood and in the pathophysiology of the stress response, and they suggest that major depression may be associated with biophysical tissue changes in the aging hippocampus.

Original language	English (US)
Pages (from-to)	387-391
Number of pages	5
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	3
Issue number	4
DOIs	https://doi.org/10.1176/jnp.3.4.387
State	Published - 1991

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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title = "Hippocampal abnormalities in depression",

abstract = "A quantitative magnetic resonance imaging study of regional brain T1 spin-lattice relaxation times in 29 normal volunteers and in 20 patients with major depression revealed significantly shortened T1 relaxation times for the hippocampus in depressed patients. These differences were particularly prominent in elderly depressed patients. T1 relaxation times are reflective of the content and macromolecular environment of tissue water protons; shorter hippocampal T1 values may reflect differences in the content or organizational properties of hippocampal water protons. These findings are consistent with several lines of evidence that have implicated a role for the hippocampus in the regulation of mood and in the pathophysiology of the stress response, and they suggest that major depression may be associated with biophysical tissue changes in the aging hippocampus.",

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T1 - Hippocampal abnormalities in depression

AU - Krishman, K. R R

AU - Doraiswamy, P. M.

AU - Figiel, G. S.

AU - Husain, M. M.

AU - Shah, S. A.

AU - Na, C.

AU - Boyko, O. B.

AU - McDonald, W. M.

AU - Nemeroff, C. B.

AU - Ellinwood, E. H.

PY - 1991

Y1 - 1991

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AB - A quantitative magnetic resonance imaging study of regional brain T1 spin-lattice relaxation times in 29 normal volunteers and in 20 patients with major depression revealed significantly shortened T1 relaxation times for the hippocampus in depressed patients. These differences were particularly prominent in elderly depressed patients. T1 relaxation times are reflective of the content and macromolecular environment of tissue water protons; shorter hippocampal T1 values may reflect differences in the content or organizational properties of hippocampal water protons. These findings are consistent with several lines of evidence that have implicated a role for the hippocampus in the regulation of mood and in the pathophysiology of the stress response, and they suggest that major depression may be associated with biophysical tissue changes in the aging hippocampus.

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Hippocampal abnormalities in depression

Abstract

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