Higher platelet distribution width predicts poor prognosis in laryngeal cancer

Huan Zhang; Li Liu; Shuang Fu; Yan Song Liu; Changsong Wang; Tiemin Liu; Zhi Ping Liu; Rui Tao Wang; Kai Jiang Yu

doi:10.18632/oncotarget.18306

Higher platelet distribution width predicts poor prognosis in laryngeal cancer

Huan Zhang, Li Liu, Shuang Fu, Yan Song Liu, Changsong Wang, Tiemin Liu, Zhi Ping Liu, Rui Tao Wang, Kai Jiang Yu

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Background: Activated platelets promote cancer progression and metastasis. However, the prognostic value of platelet indices in laryngeal cancer remains poorly understood. The purpose of this study was to investigate the predictive significance of platelet indices in laryngeal cancer. Results: Of the 241 patients, high platelet distribution width (PDW) levels were observed in 116 (48.1 %) patients. In the Kaplan-Meier analysis, increased PDW was significantly associated with a poorer overall survival (p < 0.001). In the multivariate Cox model, PDW was an independent prognostic index for overall survival (HR=4.381, 95% CI=2.313-8.298, P < 0.001). Method: The retrospective study included 241 consecutive patients with laryngeal cancer between January 2009 and December 2009. The relationships between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW. Conclusions: Elevated PDW might be a novel prognostic marker in laryngeal cancer.

Original language	English (US)
Pages (from-to)	48138-48144
Number of pages	7
Journal	Oncotarget
Volume	8
Issue number	29
DOIs	https://doi.org/10.18632/oncotarget.18306
State	Published - 2017

Keywords

Laryngeal cancer
Platelet distribution width
Prognosis
Survival

ASJC Scopus subject areas

Oncology

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title = "Higher platelet distribution width predicts poor prognosis in laryngeal cancer",

abstract = "Background: Activated platelets promote cancer progression and metastasis. However, the prognostic value of platelet indices in laryngeal cancer remains poorly understood. The purpose of this study was to investigate the predictive significance of platelet indices in laryngeal cancer. Results: Of the 241 patients, high platelet distribution width (PDW) levels were observed in 116 (48.1 %) patients. In the Kaplan-Meier analysis, increased PDW was significantly associated with a poorer overall survival (p < 0.001). In the multivariate Cox model, PDW was an independent prognostic index for overall survival (HR=4.381, 95% CI=2.313-8.298, P < 0.001). Method: The retrospective study included 241 consecutive patients with laryngeal cancer between January 2009 and December 2009. The relationships between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW. Conclusions: Elevated PDW might be a novel prognostic marker in laryngeal cancer.",

keywords = "Laryngeal cancer, Platelet distribution width, Prognosis, Survival",

author = "Huan Zhang and Li Liu and Shuang Fu and Liu, {Yan Song} and Changsong Wang and Tiemin Liu and Liu, {Zhi Ping} and Wang, {Rui Tao} and Yu, {Kai Jiang}",

note = "Publisher Copyright: {\textcopyright} Zhang et al.",

year = "2017",

doi = "10.18632/oncotarget.18306",

language = "English (US)",

volume = "8",

pages = "48138--48144",

journal = "Oncotarget",

issn = "1949-2553",

publisher = "Impact Journals",

number = "29",

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TY - JOUR

T1 - Higher platelet distribution width predicts poor prognosis in laryngeal cancer

AU - Zhang, Huan

AU - Liu, Li

AU - Fu, Shuang

AU - Liu, Yan Song

AU - Wang, Changsong

AU - Liu, Tiemin

AU - Liu, Zhi Ping

AU - Wang, Rui Tao

AU - Yu, Kai Jiang

N1 - Publisher Copyright: © Zhang et al.

PY - 2017

Y1 - 2017

N2 - Background: Activated platelets promote cancer progression and metastasis. However, the prognostic value of platelet indices in laryngeal cancer remains poorly understood. The purpose of this study was to investigate the predictive significance of platelet indices in laryngeal cancer. Results: Of the 241 patients, high platelet distribution width (PDW) levels were observed in 116 (48.1 %) patients. In the Kaplan-Meier analysis, increased PDW was significantly associated with a poorer overall survival (p < 0.001). In the multivariate Cox model, PDW was an independent prognostic index for overall survival (HR=4.381, 95% CI=2.313-8.298, P < 0.001). Method: The retrospective study included 241 consecutive patients with laryngeal cancer between January 2009 and December 2009. The relationships between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW. Conclusions: Elevated PDW might be a novel prognostic marker in laryngeal cancer.

AB - Background: Activated platelets promote cancer progression and metastasis. However, the prognostic value of platelet indices in laryngeal cancer remains poorly understood. The purpose of this study was to investigate the predictive significance of platelet indices in laryngeal cancer. Results: Of the 241 patients, high platelet distribution width (PDW) levels were observed in 116 (48.1 %) patients. In the Kaplan-Meier analysis, increased PDW was significantly associated with a poorer overall survival (p < 0.001). In the multivariate Cox model, PDW was an independent prognostic index for overall survival (HR=4.381, 95% CI=2.313-8.298, P < 0.001). Method: The retrospective study included 241 consecutive patients with laryngeal cancer between January 2009 and December 2009. The relationships between PDW and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of PDW. Conclusions: Elevated PDW might be a novel prognostic marker in laryngeal cancer.

KW - Laryngeal cancer

KW - Platelet distribution width

KW - Prognosis

KW - Survival

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DO - 10.18632/oncotarget.18306

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C2 - 28624815

AN - SCOPUS:85024362862

SN - 1949-2553

VL - 8

SP - 48138

EP - 48144

JO - Oncotarget

JF - Oncotarget

IS - 29

ER -

Higher platelet distribution width predicts poor prognosis in laryngeal cancer

Abstract

Keywords

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