High-sugar feeding and increasing cholesterol levels in infants

Petra Zubin Maslov, Joseph A. Hill, Thomas F. Lüscher, Jagat Narula

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Hypercholesterolaemia is an important risk factor for cardiovascular disease. Both total and LDL cholesterol levels are three-fold higher at the end of the first year of life and about four-fold higher in adulthood compared with the neonatal period. In the USA, only 25% of infants are exclusively breastfed and simple carbohydrate-rich formulas are preferentially consumed. Spikes in fasting glucose and insulin have been reported in formula-fed infants and are associated with higher levels of proprotein convertase subtilisin/kexin type 9, suggesting a potential link between high simple sugar intake and consequent increase in LDL cholesterol in early childhood.

Original languageEnglish (US)
Pages (from-to)1132-1135
Number of pages4
JournalEuropean heart journal
Issue number12
StatePublished - Mar 21 2021


  • Carbohydrates
  • Cardiovascular disease prevention
  • Lipid metabolism
  • Low-density lipoprotein
  • Proprotein convertase subtilisin/kexin type 9

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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