High somatostatin uptake by the isolated perfused dog pancreas consistent with an “insulo-acinar” axis

K. Kawai; L. Orci; Roger H Unger

doi:10.1210/endo-110-2-660

High somatostatin uptake by the isolated perfused dog pancreas consistent with an “insulo-acinar” axis

K. Kawai, L. Orci, Roger H Unger

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Abstract

The canine pancreas takes up 50-80% of somatostatiri perfused over a concentration range of 20 to 4000 pg/ml, compared to <21% of insulin or glucagon. This high uptake by acinar tissue of somatostatin, a potent inhibitor of acinar function, is compatible with a system for selective intrapancreatic control of exocrine pancreatic function via the insulo-acinar portal venous system.

Original language	English (US)
Pages (from-to)	660-662
Number of pages	3
Journal	Endocrinology
Volume	110
Issue number	2
DOIs	https://doi.org/10.1210/endo-110-2-660
State	Published - Feb 1982

ASJC Scopus subject areas

Endocrinology

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10.1210/endo-110-2-660

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abstract = "The canine pancreas takes up 50-80% of somatostatiri perfused over a concentration range of 20 to 4000 pg/ml, compared to <21% of insulin or glucagon. This high uptake by acinar tissue of somatostatin, a potent inhibitor of acinar function, is compatible with a system for selective intrapancreatic control of exocrine pancreatic function via the insulo-acinar portal venous system.",

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AB - The canine pancreas takes up 50-80% of somatostatiri perfused over a concentration range of 20 to 4000 pg/ml, compared to <21% of insulin or glucagon. This high uptake by acinar tissue of somatostatin, a potent inhibitor of acinar function, is compatible with a system for selective intrapancreatic control of exocrine pancreatic function via the insulo-acinar portal venous system.

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High somatostatin uptake by the isolated perfused dog pancreas consistent with an “insulo-acinar” axis

Abstract

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