High rate of survival in transformed lymphoma after autologous stem cell transplant: Pathologic analysis and comparison with de novo diffuse large B-cell lymphoma

Stephen D. Smith; Brian J. Bolwell; Anjali S. Advani; Steven W. Andresen; Josephine L. Chan; Robert M. Dean; Eric D. Hsi; Matt E. Kalaycio; Brad L. Pohlman; Lisa A. Rybicki; John W. Sweetenham

doi:10.1080/10428190903128652

High rate of survival in transformed lymphoma after autologous stem cell transplant: Pathologic analysis and comparison with de novo diffuse large B-cell lymphoma

Stephen D. Smith, Brian J. Bolwell, Anjali S. Advani, Steven W. Andresen, Josephine L. Chan, Robert M. Dean, Eric D. Hsi, Matt E. Kalaycio, Brad L. Pohlman, Lisa A. Rybicki, John W. Sweetenham

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10 Scopus citations

Abstract

Transformed lymphoma (TL) is historically associated with a poor prognosis, though autologous stem cell transplantation (ASCT) has been applied successfully. Better patient selection is needed for this intensive therapy. We analyzed the outcomes between de novo and transformed large B-cell lymphoma in patients undergoing ASCT, with regard to the immunohistochemical (IHC) features of potential prognostic utility including CD10, BCL6, MUM-1, Ki67, and BCL2. Of all patients undergoing ASCT for large B-cell lymphoma at the Cleveland Clinic Taussig Cancer Institute between 2003 and 2008, 56 patients (31 de novo and 25 TL) had undergone detailed IHC analysis. Three-year relapse-free-survival (RFS) and overall survival (OS) for TL_vs. patients with de novo large B-cell lymphoma were 64%_vs. 59% and 63%_vs. 59%, respectively. More patients with TL were characterized as germinal-center B cell-of-origin (92%) than patients with de novo large B-cell lymphoma (71%). Immunohistochemistry did not predict relapse-free or overall survival, and ASCT afforded a high rate of PFS in patients with TL.

Original language	English (US)
Pages (from-to)	1625-1631
Number of pages	7
Journal	Leukemia and Lymphoma
Volume	50
Issue number	10
DOIs	https://doi.org/10.1080/10428190903128652
State	Published - 2009
Externally published	Yes

Keywords

Clinical results
Lymphoma and hodgkin disease
Prognostication

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1080/10428190903128652

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Smith, S. D., Bolwell, B. J., Advani, A. S., Andresen, S. W., Chan, J. L., Dean, R. M., Hsi, E. D., Kalaycio, M. E., Pohlman, B. L., Rybicki, L. A., & Sweetenham, J. W. (2009). High rate of survival in transformed lymphoma after autologous stem cell transplant: Pathologic analysis and comparison with de novo diffuse large B-cell lymphoma. Leukemia and Lymphoma, 50(10), 1625-1631. https://doi.org/10.1080/10428190903128652

Smith, SD, Bolwell, BJ, Advani, AS, Andresen, SW, Chan, JL, Dean, RM, Hsi, ED, Kalaycio, ME, Pohlman, BL, Rybicki, LA & Sweetenham, JW 2009, 'High rate of survival in transformed lymphoma after autologous stem cell transplant: Pathologic analysis and comparison with de novo diffuse large B-cell lymphoma', Leukemia and Lymphoma, vol. 50, no. 10, pp. 1625-1631. https://doi.org/10.1080/10428190903128652

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title = "High rate of survival in transformed lymphoma after autologous stem cell transplant: Pathologic analysis and comparison with de novo diffuse large B-cell lymphoma",

abstract = "Transformed lymphoma (TL) is historically associated with a poor prognosis, though autologous stem cell transplantation (ASCT) has been applied successfully. Better patient selection is needed for this intensive therapy. We analyzed the outcomes between de novo and transformed large B-cell lymphoma in patients undergoing ASCT, with regard to the immunohistochemical (IHC) features of potential prognostic utility including CD10, BCL6, MUM-1, Ki67, and BCL2. Of all patients undergoing ASCT for large B-cell lymphoma at the Cleveland Clinic Taussig Cancer Institute between 2003 and 2008, 56 patients (31 de novo and 25 TL) had undergone detailed IHC analysis. Three-year relapse-free-survival (RFS) and overall survival (OS) for TLvs. patients with de novo large B-cell lymphoma were 64%vs. 59% and 63%vs. 59%, respectively. More patients with TL were characterized as germinal-center B cell-of-origin (92%) than patients with de novo large B-cell lymphoma (71%). Immunohistochemistry did not predict relapse-free or overall survival, and ASCT afforded a high rate of PFS in patients with TL.",

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author = "Smith, {Stephen D.} and Bolwell, {Brian J.} and Advani, {Anjali S.} and Andresen, {Steven W.} and Chan, {Josephine L.} and Dean, {Robert M.} and Hsi, {Eric D.} and Kalaycio, {Matt E.} and Pohlman, {Brad L.} and Rybicki, {Lisa A.} and Sweetenham, {John W.}",

year = "2009",

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AU - Dean, Robert M.

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AB - Transformed lymphoma (TL) is historically associated with a poor prognosis, though autologous stem cell transplantation (ASCT) has been applied successfully. Better patient selection is needed for this intensive therapy. We analyzed the outcomes between de novo and transformed large B-cell lymphoma in patients undergoing ASCT, with regard to the immunohistochemical (IHC) features of potential prognostic utility including CD10, BCL6, MUM-1, Ki67, and BCL2. Of all patients undergoing ASCT for large B-cell lymphoma at the Cleveland Clinic Taussig Cancer Institute between 2003 and 2008, 56 patients (31 de novo and 25 TL) had undergone detailed IHC analysis. Three-year relapse-free-survival (RFS) and overall survival (OS) for TLvs. patients with de novo large B-cell lymphoma were 64%vs. 59% and 63%vs. 59%, respectively. More patients with TL were characterized as germinal-center B cell-of-origin (92%) than patients with de novo large B-cell lymphoma (71%). Immunohistochemistry did not predict relapse-free or overall survival, and ASCT afforded a high rate of PFS in patients with TL.

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High rate of survival in transformed lymphoma after autologous stem cell transplant: Pathologic analysis and comparison with de novo diffuse large B-cell lymphoma

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