Abstract
Aim: To examine whether dynamic characteristics of the peripheral vagal control of heart rate (HR) are altered in chronic heart failure (CHF). Methods: The right vagal nerve was electrically stimulated according to a binary white noise signal, and the transfer function from vagal nerve stimulation (VNS) to HR was estimated in the frequency range from 0.01 to 1 Hz in five control rats and five CHF rats under anaesthetized conditions. The rate of VNS was changed among 10, 20 and 40 Hz. Results: A multiple linear regression analysis indicated that the increase in the VNS rate augmented the ratio of the high-frequency (HF) gain to the steady-state gain in the control group but not in the CHF group. As a result, the dynamic gain of the transfer function in the frequencies near 1 Hz decreased more in the CHF group than in the control group. Conclusion: Changes in the dynamic characteristics of the peripheral vagal control of HR may contribute to the manifestation of decreased HF components of HR variability observed in CHF.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 494-502 |
| Number of pages | 9 |
| Journal | Acta Physiologica |
| Volume | 207 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2013 |
Keywords
- Transfer function
- Vagal nerve stimulation
- White noise analysis
ASJC Scopus subject areas
- Physiology