TY - JOUR
T1 - Heterotopic ossification following burn injury
T2 - The role of stem cells
AU - Nelson, Emily R.
AU - Wong, Victor W.
AU - Krebsbach, Paul H.
AU - Wang, Stewart C.
AU - Levi, Benjamin
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - Heterotopic ossification (HO), or the abnormal development of bone tissue in soft-tissue locations, can be physically debilitating and clinically devastating. For unclear reasons, HO is highly associated with burn injury. The objective of this review is to summarize 1) cells that are responsible for HO, 2) in vitro and in vivo models of HO and how they have contributed to our current knowledge of the disease process, 3) the effects of the adipose compartment on HO, 4) the effects of inflammation on HO, and 5) the effects of mesenchymal stem cells (MSCs) on HO. Preclinical models of HO suggest several possible mechanisms for the development of this pathologic process, including progenitor cell differentiation and paracrine modulation of local inflammatory responses. Further studies are needed to elucidate the molecular mechanisms driving HO so that targeted therapies can be developed. Current literature supports a role for MSCs in modulating heterotopic bone formation, and direct manipulation of MSCs might one day be used to prevent and treat HO. (J Burn Care Res 2012;33:463-470).
AB - Heterotopic ossification (HO), or the abnormal development of bone tissue in soft-tissue locations, can be physically debilitating and clinically devastating. For unclear reasons, HO is highly associated with burn injury. The objective of this review is to summarize 1) cells that are responsible for HO, 2) in vitro and in vivo models of HO and how they have contributed to our current knowledge of the disease process, 3) the effects of the adipose compartment on HO, 4) the effects of inflammation on HO, and 5) the effects of mesenchymal stem cells (MSCs) on HO. Preclinical models of HO suggest several possible mechanisms for the development of this pathologic process, including progenitor cell differentiation and paracrine modulation of local inflammatory responses. Further studies are needed to elucidate the molecular mechanisms driving HO so that targeted therapies can be developed. Current literature supports a role for MSCs in modulating heterotopic bone formation, and direct manipulation of MSCs might one day be used to prevent and treat HO. (J Burn Care Res 2012;33:463-470).
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U2 - 10.1097/BCR.0b013e31825af547
DO - 10.1097/BCR.0b013e31825af547
M3 - Review article
C2 - 22683987
AN - SCOPUS:85027958354
SN - 1559-047X
VL - 33
SP - 463
EP - 470
JO - Journal of Burn Care and Research
JF - Journal of Burn Care and Research
IS - 4
ER -