TY - JOUR
T1 - Heterotopic ossification
T2 - Basic-science principles and clinical correlates
AU - Ranganathan, Kavitha
AU - Loder, Shawn
AU - Agarwal, Shailesh
AU - Wong, Victor W.
AU - Forsberg, Jonathan
AU - Davis, Thomas A.
AU - Wang, Stewart
AU - James, Aaron W.
AU - Levi, Benjamin
N1 - Publisher Copyright:
© 2015 by the Journal of Bone and Joint Surgery, Incorporated.
PY - 2014/9/2
Y1 - 2014/9/2
N2 - Heterotopic ossification occurs most commonly after joint arthroplasty, spinal cord injury, traumatic brain injury, blast trauma, elbow and acetabular fractures, and thermal injury. The conversion of progenitor cells to osteogenic precursor cells as a result of cell-mediated interactions with the local tissue environment is affected by oxygen tension, pH, availability of micronutrients, and mechanical stimuli, and leads to heterotopic ossification. Radiation and certain nonsteroidal anti-inflammatory medications are important methods of prophylaxis against heterotopic ossification. Well-planned surgical excision can improve patient outcomes regardless of the joint involved or the initial cause of injury. Future therapeutic strategies are focused on targeted inhibition of local factors and signaling pathways that catalyze ectopic bone formation.
AB - Heterotopic ossification occurs most commonly after joint arthroplasty, spinal cord injury, traumatic brain injury, blast trauma, elbow and acetabular fractures, and thermal injury. The conversion of progenitor cells to osteogenic precursor cells as a result of cell-mediated interactions with the local tissue environment is affected by oxygen tension, pH, availability of micronutrients, and mechanical stimuli, and leads to heterotopic ossification. Radiation and certain nonsteroidal anti-inflammatory medications are important methods of prophylaxis against heterotopic ossification. Well-planned surgical excision can improve patient outcomes regardless of the joint involved or the initial cause of injury. Future therapeutic strategies are focused on targeted inhibition of local factors and signaling pathways that catalyze ectopic bone formation.
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U2 - 10.2106/JBJS.N.01056
DO - 10.2106/JBJS.N.01056
M3 - Review article
C2 - 26135077
AN - SCOPUS:84941096625
SN - 0021-9355
VL - 97
SP - 1101
EP - 1111
JO - Journal of Bone and Joint Surgery - American Volume
JF - Journal of Bone and Joint Surgery - American Volume
IS - 13
ER -