TY - JOUR
T1 - Heterologous prime-boost immunizations with different Salmonella serovars for enhanced antigen-specific CD8 T-cell induction
AU - Sevil Domènech, Victòria E.
AU - Panthel, Klaus
AU - Winter, Sebastian E.
AU - Rüssmann, Holger
N1 - Funding Information:
H.R. was supported by the Deutsche Forschungsgemeinschaft (Schwerpunktprogramm “Neue Vakzinierungsstrategien”, grant RU 838/1-3).
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2008/3/28
Y1 - 2008/3/28
N2 - Pre-existing anti-vector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. In the present study, we demonstrate that heterologous prime-boost immunizations using attenuated serovar Typhimurium and serovar Dublin strains for foreign antigen delivery can be employed to bypass anti-Salmonella immunity resulting in enhanced antigen-specific CD8 T-cell induction. This desirable effect can be explained by the fact that, in contrast to homologous prime-boost immunizations, vaccination with different Salmonella serovars is characterized by long-lasting colonization of mice by both live carrier vaccines.
AB - Pre-existing anti-vector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. In the present study, we demonstrate that heterologous prime-boost immunizations using attenuated serovar Typhimurium and serovar Dublin strains for foreign antigen delivery can be employed to bypass anti-Salmonella immunity resulting in enhanced antigen-specific CD8 T-cell induction. This desirable effect can be explained by the fact that, in contrast to homologous prime-boost immunizations, vaccination with different Salmonella serovars is characterized by long-lasting colonization of mice by both live carrier vaccines.
KW - Anti-vector immunity
KW - CD8 T cell
KW - Heterologous prime-boost immunizations
KW - Salmonella enterica serovar Typhimurium and serovar Dublin
KW - Type III secretion system
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U2 - 10.1016/j.vaccine.2008.01.044
DO - 10.1016/j.vaccine.2008.01.044
M3 - Article
C2 - 18313813
AN - SCOPUS:40849135857
SN - 0264-410X
VL - 26
SP - 1879
EP - 1886
JO - Vaccine
JF - Vaccine
IS - 15
ER -