Heterogeneous Nucleation of Calcium Oxalate by Seeds of Monosodium Urate

C. Y C Pak, L. H. Arnold

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


Seeds of monosodium urate caused heterogeneous nucleation of calcium oxalate at pH 5.7 and 6.7, and of calcium phosphate at pH 5.3, 5.7, and 6.7 from metastably supersaturated solutions in vitro. Seeds of uric acid had a small or no effect. The results could account for the formation of calcium stones among patients with hyperuricosuria and normocalciuria. This work was supported by a Grant from the USPHS (R01-AM16061) and by a Grant from Burroughs-Wellcome Co.

Original languageEnglish (US)
Pages (from-to)930-932
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number4
StatePublished - Sep 8 1975

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Heterogeneous Nucleation of Calcium Oxalate by Seeds of Monosodium Urate'. Together they form a unique fingerprint.

Cite this