Hepatocyte-specific hmgb1 deletion

Xiaofang Sun; Daolin Tang

doi:10.1080/15548627.2015.1054595

Hepatocyte-specific hmgb1 deletion

Xiaofang Sun, Daolin Tang

Research output: Contribution to journal › Comment/debate › peer-review

3 Scopus citations

Abstract

High mobility group box 1 (HMGB1) plays a key role in human health and disease. Currently, three different labs in the USA use Crelox technology to create mice with a hepatocyte-specific Hmgb1 deletion (HMGB1-HC-KO mice) by backcrossing Hmgb1 ^flox/flox mice to Alb-Cre mice. This mouse strain has a different phenotype following exposure to several stressors.

Original language	English (US)
Pages (from-to)	1189-1191
Number of pages	3
Journal	Autophagy
Volume	11
Issue number	7
DOIs	https://doi.org/10.1080/15548627.2015.1054595
State	Published - Jan 1 2015
Externally published	Yes

Keywords

HMGB1
Knockout
Liver
Mice

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1080/15548627.2015.1054595

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title = "Hepatocyte-specific hmgb1 deletion",

abstract = "High mobility group box 1 (HMGB1) plays a key role in human health and disease. Currently, three different labs in the USA use Crelox technology to create mice with a hepatocyte-specific Hmgb1 deletion (HMGB1-HC-KO mice) by backcrossing Hmgb1 flox/flox mice to Alb-Cre mice. This mouse strain has a different phenotype following exposure to several stressors.",

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author = "Xiaofang Sun and Daolin Tang",

note = "Publisher Copyright: {\textcopyright} 2015, Taylor and Francis Group, LLC.",

year = "2015",

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doi = "10.1080/15548627.2015.1054595",

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AU - Sun, Xiaofang

AU - Tang, Daolin

PY - 2015/1/1

Y1 - 2015/1/1

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AB - High mobility group box 1 (HMGB1) plays a key role in human health and disease. Currently, three different labs in the USA use Crelox technology to create mice with a hepatocyte-specific Hmgb1 deletion (HMGB1-HC-KO mice) by backcrossing Hmgb1 flox/flox mice to Alb-Cre mice. This mouse strain has a different phenotype following exposure to several stressors.

KW - HMGB1

KW - Knockout

KW - Liver

KW - Mice

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M3 - Comment/debate

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JO - Autophagy

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ER -

Hepatocyte-specific hmgb1 deletion

Abstract

Keywords

ASJC Scopus subject areas

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