Hepatocellular Carcinoma Chemoprevention with Generic Agents

Fahmida Rasha, Subhojit Paul, Tracey G. Simon, Yujin Hoshida

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Liver cancer, mainly hepatocellular carcinoma (HCC), remains a major cause of cancerrelated death worldwide.With the global epidemic of obesity, the major HCC etiologies have been dynamically shifting from viral to metabolic liver diseases. This change has made HCC prevention difficult with increasingly elusive at-risk populations as rational target for preventive interventions. Besides ongoing efforts to reduce obesity and metabolic disorders, chemoprevention in patients who already have metabolic liver diseases may have a significant impact on the poor HCC prognosis. Hepatitis B- and hepatitis C-related HCC incidences have been substantially reduced by the new antivirals, but HCC risk can persist over a decade even after successful viral treatment, highlighting the need for HCC-preventivemeasures also in these patients. Experimental and retrospective studies have suggested potential utility of generic agents such as lipophilic statins and aspirin for HCC chemoprevention given their well-characterized safety profile, although anticipated efficacy may bemodest. In this review, we overview recent clinical and translational studies of generic agents in the context of HCC chemoprevention under the contemporary HCC etiologies. We also discuss newly emerging approaches to overcome the challenges in clinical testing of the agents to facilitate their clinical translation.

Original languageEnglish (US)
Pages (from-to)501-513
Number of pages13
JournalSeminars in liver disease
Issue number4
StatePublished - Nov 1 2022
Externally publishedYes


  • biomarker
  • chemoprevention
  • drug repurposing
  • generic agent
  • hepatocellular carcinoma

ASJC Scopus subject areas

  • Hepatology


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