Hepatic bilirubin UDP-glucuronyltransferase in patients with sickle cell anemia

Willis C. Maddrey; Julio O. Cukier; Apolo C. Maglalang; John K. Boitnott; Gerard B. Odell

doi:10.1016/0016-5085(78)90794-1

Hepatic bilirubin UDP-glucuronyltransferase in patients with sickle cell anemia

Willis C. Maddrey, Julio O. Cukier, Apolo C. Maglalang, John K. Boitnott, Gerard B. Odell

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

In sickle cell anemia the shortened survival of red blood cells presents the liver with an augmented load of bilirubin for hepatic clearance. To determine the effects of this excessive bilirubin load on the microsomal conjugating enzyme, hepatic bilirubin UDP-glucuronyltransferase, levels of this enzyme were measured in liver biopsies from patients with sickle cell anemia and several comparison groups. UDP-glucuronyltransferase activity in 14 patients with sickle cell anemia was 2-fold greater (P < 0.005) than in 14 nonjaundiced comparison patients without liver disease. The elevated UDP-glucuronyltransferase activity in sickle cell anemia was similar to that found in 10 patients who chronically ingested drugs (barbiturates or estrogens) known to increase UDP-glucuronyltransferase activity. These obseverations suggest enhanced conjugation of bilirubin in patients with sickle cell anemia may result from substrate (bilirubin) induction of UDP-glycuronyltransferase.

Original language	English (US)
Pages (from-to)	193-195
Number of pages	3
Journal	Gastroenterology
Volume	74
Issue number	2 PART 1
DOIs	https://doi.org/10.1016/0016-5085(78)90794-1
State	Published - Feb 1978

ASJC Scopus subject areas

Hepatology
Gastroenterology

Access to Document

10.1016/0016-5085(78)90794-1

Cite this

@article{352ec06e2320402aaa2522aeb6cd8def,

title = "Hepatic bilirubin UDP-glucuronyltransferase in patients with sickle cell anemia",

abstract = "In sickle cell anemia the shortened survival of red blood cells presents the liver with an augmented load of bilirubin for hepatic clearance. To determine the effects of this excessive bilirubin load on the microsomal conjugating enzyme, hepatic bilirubin UDP-glucuronyltransferase, levels of this enzyme were measured in liver biopsies from patients with sickle cell anemia and several comparison groups. UDP-glucuronyltransferase activity in 14 patients with sickle cell anemia was 2-fold greater (P < 0.005) than in 14 nonjaundiced comparison patients without liver disease. The elevated UDP-glucuronyltransferase activity in sickle cell anemia was similar to that found in 10 patients who chronically ingested drugs (barbiturates or estrogens) known to increase UDP-glucuronyltransferase activity. These obseverations suggest enhanced conjugation of bilirubin in patients with sickle cell anemia may result from substrate (bilirubin) induction of UDP-glycuronyltransferase.",

author = "Maddrey, {Willis C.} and Cukier, {Julio O.} and Maglalang, {Apolo C.} and Boitnott, {John K.} and Odell, {Gerard B.}",

year = "1978",

month = feb,

doi = "10.1016/0016-5085(78)90794-1",

language = "English (US)",

volume = "74",

pages = "193--195",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders Ltd",

number = "2 PART 1",

}

TY - JOUR

T1 - Hepatic bilirubin UDP-glucuronyltransferase in patients with sickle cell anemia

AU - Maddrey, Willis C.

AU - Cukier, Julio O.

AU - Maglalang, Apolo C.

AU - Boitnott, John K.

AU - Odell, Gerard B.

PY - 1978/2

Y1 - 1978/2

N2 - In sickle cell anemia the shortened survival of red blood cells presents the liver with an augmented load of bilirubin for hepatic clearance. To determine the effects of this excessive bilirubin load on the microsomal conjugating enzyme, hepatic bilirubin UDP-glucuronyltransferase, levels of this enzyme were measured in liver biopsies from patients with sickle cell anemia and several comparison groups. UDP-glucuronyltransferase activity in 14 patients with sickle cell anemia was 2-fold greater (P < 0.005) than in 14 nonjaundiced comparison patients without liver disease. The elevated UDP-glucuronyltransferase activity in sickle cell anemia was similar to that found in 10 patients who chronically ingested drugs (barbiturates or estrogens) known to increase UDP-glucuronyltransferase activity. These obseverations suggest enhanced conjugation of bilirubin in patients with sickle cell anemia may result from substrate (bilirubin) induction of UDP-glycuronyltransferase.

AB - In sickle cell anemia the shortened survival of red blood cells presents the liver with an augmented load of bilirubin for hepatic clearance. To determine the effects of this excessive bilirubin load on the microsomal conjugating enzyme, hepatic bilirubin UDP-glucuronyltransferase, levels of this enzyme were measured in liver biopsies from patients with sickle cell anemia and several comparison groups. UDP-glucuronyltransferase activity in 14 patients with sickle cell anemia was 2-fold greater (P < 0.005) than in 14 nonjaundiced comparison patients without liver disease. The elevated UDP-glucuronyltransferase activity in sickle cell anemia was similar to that found in 10 patients who chronically ingested drugs (barbiturates or estrogens) known to increase UDP-glucuronyltransferase activity. These obseverations suggest enhanced conjugation of bilirubin in patients with sickle cell anemia may result from substrate (bilirubin) induction of UDP-glycuronyltransferase.

UR - http://www.scopus.com/inward/record.url?scp=0017839876&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017839876&partnerID=8YFLogxK

U2 - 10.1016/0016-5085(78)90794-1

DO - 10.1016/0016-5085(78)90794-1

M3 - Article

C2 - 413760

AN - SCOPUS:0017839876

SN - 0016-5085

VL - 74

SP - 193

EP - 195

JO - Gastroenterology

JF - Gastroenterology

IS - 2 PART 1

ER -

Hepatic bilirubin UDP-glucuronyltransferase in patients with sickle cell anemia

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this