Hemodynamic Stability in Medically Treated Hypothyroid Patients Undergoing Intravenous Sedation

Purpose: To evaluate the hemodynamic stability of medically treated hypothyroid patients undergoing intravenous sedation for dentoalveolar surgery. Patients and Methods: A retrospective chart analysis of 20 consecutive white male patients actively being treated for hypothyroidism undergoing intravenous sedation for dentoalveolar surgery. Twenty consecutive normothyroid white male patients undergoing intravenous sedation for dentoalveolar surgery were used as controls. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), pulse pressure (PP), peripheral oxygen saturation (S_pO₂) and pulse were recorded at 5-minute intervals during intravenous sedation. Results: Statistically significant lower average hemodynamic values were seen in hypothyroid patients compared to normothyroid patients in SBP (P = .05) and PP (P = .003). There were highly significant baseline changes for hypothyroid patients in DBP (P < .001) and MAP (P < .001) and significant baseline changes for normothyroid patients in DBP (P = .03), PP (P = .02) and pulse (P = .03). All changes were maintained within ± 10% of baseline (range, -8.9% to +9.6%). Conclusions: Intravenous sedation for dentoalveolar surgery in medically treated hypothyroid patients maintains hemodynamic stability.