Helicobacter pylori and gastrointestinal polyps

Robert M. Genta, Richard H. Lash

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Polyps of the gastrointestinal tract are mucosal elevations that may have a mechanical, developmental, inflammatory, or neoplastic pathogenesis. Therefore, it is not surprising that there is no specific relationship between gastrointestinal polyps and H. pylori infection. In the stomach, inflammatory and proliferative responses, irrespective of their etiology, seem to favor the development of inflammatory polyps. Intact oxyntic glands, unaffected by inflammatory changes, seem to be more vulnerable to focal dilatations induced by proton pump inhibitors, hence the strong negative association of these nonneoplastic, noninflammatory polyps with H. pylori gastritis. Gastric adenomas, precursors of adenocarcinoma, are likely related to H. pylori infection by the same mechanisms that link this infection to gastric cancer. In the colon, the indisputable association of H. pylori gastritis with both hyperplastic and neoplastic polyps remains largely unexplained.

Original languageEnglish (US)
Title of host publicationHelicobacter pylori Research: From Bench to Bedside
PublisherSpringer Japan
Number of pages16
ISBN (Electronic)9784431559368
ISBN (Print)9784431559344
StatePublished - Jan 1 2016


  • Carcinoids
  • Colon polyps
  • Duodenal adenomas
  • Fundic gland polyps
  • Gastric adenomas
  • Gastric hyperplastic polyps
  • Gastric inflammatory fibroid polyps
  • Gastric neuroendocrine tumors
  • Helicobacter pylori

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)


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