Heat exposure and bicycling trigger recurrent aseptic meningitis: A case report

Olaf Stuve, Ellen Marder, Annette Okai, Mark Stettner, Bernd C. Kieseier

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Aseptic meningitis associated with herpes simplex virus type 2 often has a relapsing-remitting clinical phenotype. Factors that lead to disease activation and reactivation are currently incompletely understood. Case presentation: We describe the case of a 49-year-old Caucasian man who developed recurrent episodes of herpes simplex virus type 2-associated aseptic meningitis in the setting of heat exposure and bicycling. This case is compelling in that substantial data were available to the examining physicians on the amount of physical exercise and heat exposure. Strenuous physical activities or heat exposure in isolation did not cause re-occurrence of clinical signs and symptoms. Conclusions: This case illustrates that the dual activation of mechanical and temperature receptors in dorsal root ganglia may lead to the recurrent reactivation and afferent dissemination of latent herpes simplex virus type 2 in some patients.

Original languageEnglish (US)
Article number230
JournalBMC Neurology
Issue number1
StatePublished - Dec 31 2014

ASJC Scopus subject areas

  • Clinical Neurology


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