HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML

Medicine & Life Sciences

• entinostat 100%
• Apoptosis Regulatory Proteins 72%
• Histone Deacetylases 71%
• Acute Myeloid Leukemia 58%
• Leukemia 50%
• Transcription Factors 45%
• Myeloid Cells 26%
• Death Domain Receptors 21%
• Histone Deacetylase Inhibitors 20%
• Transcription Factor AP-1 19%
• Stem Cells 19%
• Noxae 12%
• Orphan Nuclear Receptors 12%
• Apoptosis 10%
• Cytoplasmic and Nuclear Receptors 8%
• Down-Regulation 6%