Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis?

Qingyun Liu; Tianyu Zuo; Peng Xu; Qi Jiang; Jie Wu; Mingyu Gan; Chongguang Yang; Ravi Prakash; Guofeng Zhu; Howard E. Takiff; Qian Gao

doi:10.1038/s41426-018-0101-6

Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis?

Qingyun Liu, Tianyu Zuo, Peng Xu, Qi Jiang, Jie Wu, Mingyu Gan, Chongguang Yang, Ravi Prakash, Guofeng Zhu, Howard E. Takiff, Qian Gao

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Compensatory mutations have been suggested to promote multidrug-resistant tuberculosis (MDR-TB) transmission, but their role in facilitating the recent transmission of MDR-TB is unclear. To investigate the epidemiological significance of compensatory mutations, we analyzed a four-year population-based collection of MDR-TB strains from Shanghai (the most populous city in China) and 1346 published global MDR-TB strains. We report that MDR-TB strains with compensatory mutations in the rpoA, rpoB, or rpoC genes were neither more frequently clustered nor found in larger clusters than those without compensatory mutations. Our results suggest that compensatory mutations are not a major contributor to the current epidemic of MDR-TB.

Original language	English (US)
Article number	101
Journal	Emerging Microbes and Infections
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41426-018-0101-6
State	Published - Dec 1 2018
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Parasitology
Microbiology
Immunology
Drug Discovery
Infectious Diseases
Virology

Access to Document

10.1038/s41426-018-0101-6

Cite this

@article{e28215a0dc8c4cd18f3417e827046852,

title = "Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis?",

abstract = "Compensatory mutations have been suggested to promote multidrug-resistant tuberculosis (MDR-TB) transmission, but their role in facilitating the recent transmission of MDR-TB is unclear. To investigate the epidemiological significance of compensatory mutations, we analyzed a four-year population-based collection of MDR-TB strains from Shanghai (the most populous city in China) and 1346 published global MDR-TB strains. We report that MDR-TB strains with compensatory mutations in the rpoA, rpoB, or rpoC genes were neither more frequently clustered nor found in larger clusters than those without compensatory mutations. Our results suggest that compensatory mutations are not a major contributor to the current epidemic of MDR-TB.",

author = "Qingyun Liu and Tianyu Zuo and Peng Xu and Qi Jiang and Jie Wu and Mingyu Gan and Chongguang Yang and Ravi Prakash and Guofeng Zhu and Takiff, {Howard E.} and Qian Gao",

note = "Funding Information: Fig. 1 Putative compensatory mutations in the rpoA, rpoB, and rpoC genes identified in this study. Each putative compensatory mutation was supported by at least two independent evolution events Publisher Copyright: {\textcopyright} 2018 The Author(s).",

year = "2018",

month = dec,

day = "1",

doi = "10.1038/s41426-018-0101-6",

language = "English (US)",

volume = "7",

journal = "Emerging Microbes and Infections",

issn = "2222-1751",