TY - JOUR
T1 - Hapten inhibition of the immune response in vitro
AU - Kettman, J.
PY - 1974/1
Y1 - 1974/1
N2 - The in vitro primary immune response of mouse spleen cells against a hapten, the 2,4,6‐trinitrophenyl (TNP) group, bound to an erythrocyte carrier is inhibited by the polyvalent, but nonimmunogenic TNP17HSA (human serum albumin) when added at the same time as the immunogen. Resistance to the effect of TNP17HSA develops in 24 h after the addition of immunogen. Sensitivity to this inhibition can be quickly re‐established after a mild physical dissociation of cell aggregates in the spleen cell cultures even 48 h after the start of a response. This sensitivity is rapidly lost again if the culture are incubated for a few hours before the TNP‐HSA is added.
AB - The in vitro primary immune response of mouse spleen cells against a hapten, the 2,4,6‐trinitrophenyl (TNP) group, bound to an erythrocyte carrier is inhibited by the polyvalent, but nonimmunogenic TNP17HSA (human serum albumin) when added at the same time as the immunogen. Resistance to the effect of TNP17HSA develops in 24 h after the addition of immunogen. Sensitivity to this inhibition can be quickly re‐established after a mild physical dissociation of cell aggregates in the spleen cell cultures even 48 h after the start of a response. This sensitivity is rapidly lost again if the culture are incubated for a few hours before the TNP‐HSA is added.
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U2 - 10.1002/eji.1830040113
DO - 10.1002/eji.1830040113
M3 - Article
C2 - 4852221
AN - SCOPUS:0015965096
SN - 0014-2980
VL - 4
SP - 49
EP - 53
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 1
ER -