Guidelines for the prevention of intravascular catheter-related infections

Naomi P. O'Grady, Mary Alexander, E. Patchen Dellinger, Julie L. Gerberding, Stephen O. Heard, Dennis G. Maki, Henry Masur, Rita D. McCormick, Leonard A. Mermel, Michele L. Pearson, Issam I. Raad, Adrienne Randolph, Robert A. Weinstein, Jane D. Siegel, Raymond Y W Chinn, Alfred DeMaria, James T. Lee, William A. Rutala, Elaine L. Larson, Ramon E. MoncadaWilliam E. Scheckler, Beth H. Stover, Marjorie A. Underwood

Research output: Contribution to journalReview articlepeer-review

208 Scopus citations


Background: Although many catheter-related bloodstream infections (CR-BSIs) are preventable, measures to reduce these infections are not uniformly implemented. Objective: To update an existing evidenced-based guideline that promotes strategies to prevent CR-BSIs. Data sources: The MEDLINE database, conference proceedings, and bibliographies of review articles and book chapters were searched for relevant articles. Studies included: Laboratory-based studies, controlled clinical trials, prospective interventional trials, and epidemiological investigations. Outcome measures: Reduction in CR-BSI, catheter colonization, or catheter-related infection. Synthesis: The recommended preventive strategies with the strongest supportive evidence are education and training of healthcare providers who insert and maintain catheters; maximal sterile barrier precautions during central venous catheter insertion; use of a 2% chlorhexidine preparation for skin antisepsis; no routine replacement of central venous catheters for prevention of infection; and use of antiseptic/antibiotic impregnated short-term central venous catheters if the rate of infection is high despite adherence to other strategies (i.e. education and training, maximal sterile barrier precautions and 2% chlorhexidine for skin antisepsis). Conclusion: Successful implementation of these evidence-based interventions can reduce the risk for serious catheter-related infection.

Original languageEnglish (US)
Pages (from-to)476-489
Number of pages14
JournalAmerican Journal of Infection Control
Issue number8
StatePublished - Dec 2002

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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